Filed Pursuant to Rule 424(b)(5)
Registration No. 333-282261
PROSPECTUS SUPPLEMENT
(To Prospectus Dated September 20, 2024)
$2,500,000,000
Annaly Capital Management, Inc.
Common Stock
We have entered into separate distribution agency agreements, each dated December 22, 2025, with each of Barclays Capital Inc., BNP
Paribas Securities Corp., BofA Securities, Inc., BTIG, LLC, Citizens JMP Securities, LLC, Goldman Sachs & Co. LLC, J.P. Morgan Securities LLC, Keefe, Bruyette & Woods, Inc., Morgan Stanley & Co. LLC, Piper
Sandler & Co., RBC Capital Markets, LLC, UBS Securities LLC and Wells Fargo Securities, LLC, each referred to herein as a sales agent and, collectively, the sales agents, relating to shares of our common stock, par value $0.01 per share, or
our common stock, offered by this prospectus supplement and the accompanying prospectus, pursuant to an “at-the-market” offering program. In accordance with
the terms of the distribution agency agreements, we may offer and sell shares of our common stock having an aggregate offering price of up to $2,500,000,000 from time to time through the sales agents and any additional agents appointed under
separate distribution agency agreements in the future.
Our common stock is listed on the New York Stock Exchange, or the NYSE, under the
symbol “NLY.” The last reported sale price of our common stock on the NYSE on December 19, 2025 was $22.70 per share.
Sales of shares of our common stock, if any, under this prospectus supplement and the accompanying prospectus may be made in negotiated
transactions including block trades, or will be made by means of ordinary brokers’ transactions on the NYSE at market prices prevailing at the time of sale, at prices related to such prevailing market prices or at negotiated prices or through
a market maker other than on an exchange, or any other method permitted by applicable law. The sales agents will be entitled to compensation of up to 1.00% of the gross proceeds for any shares of common stock sold under the distribution agency
agreements. Under the terms of the distribution agency agreements, we may also sell our common stock to a sales agent as principal for its own account at a price agreed upon at the time of sale. If we sell shares of common stock to a sales agent as
principal, we will enter into a separate terms agreement with that sales agent, and we will describe this agreement in a separate prospectus supplement or pricing supplement.
There are restrictions on transfer and ownership of our common stock intended to, among other purposes, preserve our qualification as a real
estate investment trust, or REIT. See “Restrictions on Ownership and Transfer” in the accompanying prospectus.
Investing in our common stock involves risks. You should carefully consider the risks described under the caption “Risk
Factors” beginning on page S-6 of this prospectus supplement and included in our most recent Annual Report on Form 10-K, as updated by any subsequent
Quarterly Reports on Form 10-Q, which are incorporated by reference into this prospectus supplement.
Neither the Securities and Exchange Commission, or the SEC, nor any state securities commission has approved or disapproved of these
securities or determined if this prospectus supplement or the accompanying prospectus to which it relates is truthful or complete. Any representation to the contrary is a criminal offense.
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| Barclays |
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BNP PARIBAS |
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BofA Securities |
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BTIG |
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| Citizens Capital Markets |
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Goldman Sachs & Co. LLC |
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J.P. Morgan |
| Keefe, Bruyette & Woods |
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Morgan Stanley |
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Piper Sandler |
| A Stifel Company |
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| RBC Capital Markets |
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UBS Investment Bank |
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Wells Fargo Securities |
The date of this prospectus supplement is December 22, 2025