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  <xsd:element name="ShareBasedCompensationLongTermIncentivePlan" id="hcm_ShareBasedCompensationLongTermIncentivePlan" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="ResearchAndDevelopmentExpensesPayableCurrent" id="hcm_ResearchAndDevelopmentExpensesPayableCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="DeferredGovernmentIncentivesCurrent" id="hcm_DeferredGovernmentIncentivesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="LongTermIncentivePlanMember" id="hcm_LongTermIncentivePlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ClassificationOfAwardsByVestingScheduleAxis" id="hcm_ClassificationOfAwardsByVestingScheduleAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ClassificationOfAwardsByVestingScheduleDomain" id="hcm_ClassificationOfAwardsByVestingScheduleDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AwardsVestingInFourYearsMember" id="hcm_AwardsVestingInFourYearsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardVestingPercentageUponFirstAnniversary" id="hcm_ShareBasedCompensationArrangementByShareBasedPaymentAwardVestingPercentageUponFirstAnniversary" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardVestingPercentageAnnuallyAfterFirstAnniversary" id="hcm_ShareBasedCompensationArrangementByShareBasedPaymentAwardVestingPercentageAnnuallyAfterFirstAnniversary" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="ContractualTermAbstract" id="hcm_ContractualTermAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValueExercisedIntrinsicValueTableTextBlock" id="hcm_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValueExercisedIntrinsicValueTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ClassificationOfAwardsByTermAxis" id="hcm_ClassificationOfAwardsByTermAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ClassificationOfAwardsByTermDomain" id="hcm_ClassificationOfAwardsByTermDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="HCMLShareOptionSchemeMember" id="hcm_HCMLShareOptionSchemeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumAmountPerAnnum" id="hcm_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumAmountPerAnnum" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="ScheduleOfAllowanceForDoubtfulAccountsTableTextBlock" id="hcm_ScheduleOfAllowanceForDoubtfulAccountsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShanghaiHutchisonPharmaceuticalsLimitedMember" id="hcm_ShanghaiHutchisonPharmaceuticalsLimitedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EquityMethodInvestmentsCompositionTableTextBlock" id="hcm_EquityMethodInvestmentsCompositionTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EquityMethodInvestmentsSummarizedFinancialInformationBalanceSheetTableTextBlock" id="hcm_EquityMethodInvestmentsSummarizedFinancialInformationBalanceSheetTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EquityMethodInvestmentsSummarizedFinancialInformationStatementOfOperationsTableTextBlock" id="hcm_EquityMethodInvestmentsSummarizedFinancialInformationStatementOfOperationsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EquityMethodInvestmentsUnderlyingEquityInNetAssetsReconciliationTableTextBlock" id="hcm_EquityMethodInvestmentsUnderlyingEquityInNetAssetsReconciliationTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="TransfersBetweenReserves" id="hcm_TransfersBetweenReserves" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="IncomeTaxReconciliationOtherJurisdictionsIncomeTaxRateDifferential" id="hcm_IncomeTaxReconciliationOtherJurisdictionsIncomeTaxRateDifferential" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="IncomeTaxReconciliationPreviouslyUnrecognizedTaxLosses" id="hcm_IncomeTaxReconciliationPreviouslyUnrecognizedTaxLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="IncomeTaxReconciliationWithholdingTaxOnUndistributedEarningsOfEquityInvestees" id="hcm_IncomeTaxReconciliationWithholdingTaxOnUndistributedEarningsOfEquityInvestees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="OtherReceivablePrepaymentsAndDepositsAbstract" id="hcm_OtherReceivablePrepaymentsAndDepositsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScheduleOfOtherReceivablesPrepaymentsAndDepositsTableTextBlock" id="hcm_ScheduleOfOtherReceivablesPrepaymentsAndDepositsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AllowanceForDoubtfulAccountsReceivableDueToExchangeDifference" id="hcm_AllowanceForDoubtfulAccountsReceivableDueToExchangeDifference" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="TimeDepositMaturityPeriod" id="hcm_TimeDepositMaturityPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LeaseholdLand" id="hcm_LeaseholdLand" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="IncreaseDecreaseInOtherPayablesAccrualsAndAdvances" id="hcm_IncreaseDecreaseInOtherPayablesAccrualsAndAdvances" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="RelatedPartyTransactionResearchAndDevelopmentServicesMember" id="hcm_RelatedPartyTransactionResearchAndDevelopmentServicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RelatedPartyTransactionSalesOfGoodsMember" id="hcm_RelatedPartyTransactionSalesOfGoodsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RelatedPartyTransactionManagementServiceMember" id="hcm_RelatedPartyTransactionManagementServiceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LitigationAbstract" id="hcm_LitigationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LitigationTextBlock" id="hcm_LitigationTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AccruedGeneralAdministrationAndOtherExpenses" id="hcm_AccruedGeneralAdministrationAndOtherExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="ScheduleOfBalancesWithRelatedPartyTransactionsTableTextBlock" id="hcm_ScheduleOfBalancesWithRelatedPartyTransactionsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ReconciliationOfNetIncomeLossToNetCashUsedInGeneratedFromOperatingActivitiesTextBlock" id="hcm_ReconciliationOfNetIncomeLossToNetCashUsedInGeneratedFromOperatingActivitiesTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ReconciliationOfNetIncomeLossToNetCashUsedInGeneratedFromOperatingActivitiesTableTextBlock" id="hcm_ReconciliationOfNetIncomeLossToNetCashUsedInGeneratedFromOperatingActivitiesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ClinicalTrialRelatedCosts" id="hcm_ClinicalTrialRelatedCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPurchasedInPeriod" id="hcm_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPurchasedInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValuePurchases" id="hcm_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValuePurchases" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationReclassifiedFromLiabilityToAdditionalPaidInCapital" id="hcm_ShareBasedCompensationReclassifiedFromLiabilityToAdditionalPaidInCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="OtherReceivablesPrepaymentsAndDepositsCurrent" id="hcm_OtherReceivablesPrepaymentsAndDepositsCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="TreasurySharesLongTermIncentivePlanHeldByTrustee" id="hcm_TreasurySharesLongTermIncentivePlanHeldByTrustee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="OtherReceivablePrepaymentsAndDepositsDisclosureTextBlock" id="hcm_OtherReceivablePrepaymentsAndDepositsDisclosureTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueForfeited" id="hcm_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueForfeited" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="ScheduleOfAccountsPayableTableTextBlock" id="hcm_ScheduleOfAccountsPayableTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScheduleOfTransactionsWithNonControllingShareholdersOfSubsidiariesTableTextBlock" id="hcm_ScheduleOfTransactionsWithNonControllingShareholdersOfSubsidiariesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScheduleOfBalancesWithNonControllingShareholdersOfSubsidiariesTableTextBlock" id="hcm_ScheduleOfBalancesWithNonControllingShareholdersOfSubsidiariesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NoteToCondensedConsolidatedStatementsOfCashFlowsAbstract" id="hcm_NoteToCondensedConsolidatedStatementsOfCashFlowsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationPreferentialIncomeTaxRate" id="hcm_EffectiveIncomeTaxRateReconciliationPreferentialIncomeTaxRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ResearchAndDevelopmentExpensesTableTextBlock" id="hcm_ResearchAndDevelopmentExpensesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NonControllingShareholdersOfSubsidiariesMember" id="hcm_NonControllingShareholdersOfSubsidiariesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AccountsPayableDisclosureTextBlock" id="hcm_AccountsPayableDisclosureTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ContractWithCustomerLiabilityNotLaterThanOneYear" id="hcm_ContractWithCustomerLiabilityNotLaterThanOneYear" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="ContractWithCustomerLiabilityLaterThanTwoYearsAndNotLaterThanThreeYears" id="hcm_ContractWithCustomerLiabilityLaterThanTwoYearsAndNotLaterThanThreeYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="ContractWithCustomerLiabilityLaterThanOneYearAndNotLaterThanTwoYears" id="hcm_ContractWithCustomerLiabilityLaterThanOneYearAndNotLaterThanTwoYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="AllowanceForDoubtfulAccountsReceivableDecreaseDueToSubsequentCollection" id="hcm_AllowanceForDoubtfulAccountsReceivableDecreaseDueToSubsequentCollection" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="VestingCriteriaAxis" id="hcm_VestingCriteriaAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="VestingCriteriaDomain" id="hcm_VestingCriteriaDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ContractWithCustomerLiabilityLaterThanThreeYearsAndNotLaterThanFourYears" id="hcm_ContractWithCustomerLiabilityLaterThanThreeYearsAndNotLaterThanFourYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="ResearchAndDevelopmentServicesMember" id="hcm_ResearchAndDevelopmentServicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScheduleOfGrantedAwardsTableTextBlock" id="hcm_ScheduleOfGrantedAwardsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OrdinarySharesOrAmericanDepositaryShareMember" id="hcm_OrdinarySharesOrAmericanDepositaryShareMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CollaborationResearchAndDevelopmentMember" id="hcm_CollaborationResearchAndDevelopmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CommercializationServicesMember" id="hcm_CommercializationServicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OtherCollaborationRoyaltiesRevenueMember" id="hcm_OtherCollaborationRoyaltiesRevenueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OtherCollaborationLicensingRevenueMember" id="hcm_OtherCollaborationLicensingRevenueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PeriodOfRepayableOnDemandAndInterestBearing" id="hcm_PeriodOfRepayableOnDemandAndInterestBearing" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="StatusForTaxabilityAxis" id="hcm_StatusForTaxabilityAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="StatusForTaxabilityDomain" id="hcm_StatusForTaxabilityDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AgingAnalysisAxis" id="hcm_AgingAnalysisAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AgingAnalysisDomain" id="hcm_AgingAnalysisDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScheduleOfAgingAnalysisForAccountsReceivablesTableTextBlock" id="hcm_ScheduleOfAgingAnalysisForAccountsReceivablesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScheduleOfAgingAnalysisForAccountsPayableTableTextBlock" id="hcm_ScheduleOfAgingAnalysisForAccountsPayableTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LeaseArrangementTermsAxis" id="hcm_LeaseArrangementTermsAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LeaseArrangementTermsDomain" id="hcm_LeaseArrangementTermsDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SeroquelMember" id="hcm_SeroquelMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="GoodsDistributionMember" id="hcm_GoodsDistributionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OrdinarySharesOrAmericanDepositaryShareVestingBasedOnPerformanceMember" id="hcm_OrdinarySharesOrAmericanDepositaryShareVestingBasedOnPerformanceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardVestingPercentageFirstFourAnniversaries" id="hcm_ShareBasedCompensationArrangementByShareBasedPaymentAwardVestingPercentageFirstFourAnniversaries" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="UnitedStatesAndOthersMember" id="hcm_UnitedStatesAndOthersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="MarketedProductsMember" id="hcm_MarketedProductsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementsMember" id="hcm_CollaborativeArrangementsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OncologyOrImmunologySegmentMember" id="hcm_OncologyOrImmunologySegmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OtherVenturesSegmentMember" id="hcm_OtherVenturesSegmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NotLaterThanThreeMonthsMember" id="hcm_NotLaterThanThreeMonthsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="BetweenThreeMonthsToSixMonthsMember" id="hcm_BetweenThreeMonthsToSixMonthsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="BetweenSixMonthsToOneYearMember" id="hcm_BetweenSixMonthsToOneYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LaterThanOneYearMember" id="hcm_LaterThanOneYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ResearchAndDevelopmentSubsegmentMember" id="hcm_ResearchAndDevelopmentSubsegmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="MarketedProductsSubsegmentMember" id="hcm_MarketedProductsSubsegmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CorporateAndReconcilingItemsMember" id="hcm_CorporateAndReconcilingItemsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfCoreBusinessAreas" id="hcm_NumberOfCoreBusinessAreas" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AccruedCapitalExpendituresCurrent" id="hcm_AccruedCapitalExpendituresCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="FixedAssetLoanFacilityMember" id="hcm_FixedAssetLoanFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OtherPayablesAccrualsAndAdvanceReceiptsMember" id="hcm_OtherPayablesAccrualsAndAdvanceReceiptsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LossContingencyAnnualInterestRate" id="hcm_LossContingencyAnnualInterestRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LossContingencyEstimatedRecoveryCost" id="hcm_LossContingencyEstimatedRecoveryCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="GainOrLossOnSaleOfStockInSubsidiaryOrEquityMethodInvesteeDisclosureTextBlock" id="hcm_GainOrLossOnSaleOfStockInSubsidiaryOrEquityMethodInvesteeDisclosureTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="MilestonePaymentAxis" id="hcm_MilestonePaymentAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="MilestonePaymentDomain" id="hcm_MilestonePaymentDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="TransactionCostAndOthers" id="hcm_TransactionCostAndOthers" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="CapitalGainTax" id="hcm_CapitalGainTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="GainOnDivestmentOfEquityInvesteeAttributableToParent" id="hcm_GainOnDivestmentOfEquityInvesteeAttributableToParent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="RefundPaymentOfLeaseholdLandDeposit" id="hcm_RefundPaymentOfLeaseholdLandDeposit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="EquityMethodInvestmentRealizedGainOnDisposal" id="hcm_EquityMethodInvestmentRealizedGainOnDisposal" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="AccumulatedOtherComprehensiveIncomeLossAndReservesNetOfTaxTotal" id="hcm_AccumulatedOtherComprehensiveIncomeLossAndReservesNetOfTaxTotal" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="ProvisionForOtherReceivablesPrepaymentsAndDeposits" id="hcm_ProvisionForOtherReceivablesPrepaymentsAndDeposits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="EliminationAmountOfUnrealizedProfitsOnSales" id="hcm_EliminationAmountOfUnrealizedProfitsOnSales" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="MaximumAmountOfBankGuaranteeToCoverAwardAmounts" id="hcm_MaximumAmountOfBankGuaranteeToCoverAwardAmounts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="ExecutiveDirectorMember" id="hcm_ExecutiveDirectorMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="UnrealizedProfitsFromEquityMethodInvestments" id="hcm_UnrealizedProfitsFromEquityMethodInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="CustomerMember" id="hcm_CustomerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CustomerBMember" id="hcm_CustomerBMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DivestmentOfEquityInvestee" id="hcm_DivestmentOfEquityInvestee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="IncomeTaxExpensesBenefitTable" id="hcm_IncomeTaxExpensesBenefitTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IncomeTaxExpensesBenefitLineItems" id="hcm_IncomeTaxExpensesBenefitLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ContractWithCustomerLiabilityLaterThanFourYears" id="hcm_ContractWithCustomerLiabilityLaterThanFourYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="DueFromRelatedPartiesMember" id="hcm_DueFromRelatedPartiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DividendsReceivableRelatedParty" id="hcm_DividendsReceivableRelatedParty" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="OtherPayablesAccrualsAndAdvanceReceiptsTable" id="hcm_OtherPayablesAccrualsAndAdvanceReceiptsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="OtherPayablesAccrualsAndAdvanceReceiptsLineItems" id="hcm_OtherPayablesAccrualsAndAdvanceReceiptsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShortTermWorkingCapitalLoanFacilityMember" id="hcm_ShortTermWorkingCapitalLoanFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="OtherReceivablePrepaymentsAndDeposits" id="hcm_OtherReceivablePrepaymentsAndDeposits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="OneYearChinaLoanPrimeRateMember" id="hcm_OneYearChinaLoanPrimeRateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FiveYearChinaLoanPrimeRateMember" id="hcm_FiveYearChinaLoanPrimeRateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DistributionServiceFee" id="hcm_DistributionServiceFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="LicenseAndCollaborationAgreementRegulatoryApprovalMilestonePayments" id="hcm_LicenseAndCollaborationAgreementRegulatoryApprovalMilestonePayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationTemporaryDifferencesAmount" id="hcm_EffectiveIncomeTaxRateReconciliationTemporaryDifferencesAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="InmageneBiopharmaceuticalsMember" id="hcm_InmageneBiopharmaceuticalsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LicenseAndCollaborationsManufacturingSupplyMember" id="hcm_LicenseAndCollaborationsManufacturingSupplyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ProvisionForAllowanceForCreditLossOnAmountsDueFromRelatedParties" id="hcm_ProvisionForAllowanceForCreditLossOnAmountsDueFromRelatedParties" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DeemedDistributionToShareholders" id="hcm_DeemedDistributionToShareholders" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="August52024OneMember" id="hcm_August52024OneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="August52024TwoMember" id="hcm_August52024TwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ParentCompanyOfCoVenturerMember" id="hcm_ParentCompanyOfCoVenturerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="OrdinarySharesOrAmericanDepositaryShareNotVestingBasedOnPerformanceMember" id="hcm_OrdinarySharesOrAmericanDepositaryShareNotVestingBasedOnPerformanceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardVestingPercentageFirstAndSecondAnniversaries" id="hcm_ShareBasedCompensationArrangementByShareBasedPaymentAwardVestingPercentageFirstAndSecondAnniversaries" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfWeeksForVestingOccurrenceAfterDateOfCompletionOfSharePurchase" id="hcm_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfWeeksForVestingOccurrenceAfterDateOfCompletionOfSharePurchase" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ScheduleOfGeographicInformationTableTextBlock" id="hcm_ScheduleOfGeographicInformationTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="OtherPayablesAccrualsAndAdvanceReceiptsCurrent" id="hcm_OtherPayablesAccrualsAndAdvanceReceiptsCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="EquityMethodInvestmentDivestmentOfOwnershipPercentage" id="hcm_EquityMethodInvestmentDivestmentOfOwnershipPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="OtherNonCurrentLiabilitiesTextBlock" id="hcm_OtherNonCurrentLiabilitiesTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="BrandingLiabilityPayableNoncurrent" id="hcm_BrandingLiabilityPayableNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="OtherLiabilitiesNoncurrentOthers" id="hcm_OtherLiabilitiesNoncurrentOthers" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="TwoChinaBasedPrivateEquityFundsMember" id="hcm_TwoChinaBasedPrivateEquityFundsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="GuaranteedProfitGrowthTargetsPeriod" id="hcm_GuaranteedProfitGrowthTargetsPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CappedCompensationPaymentUponGuaranteedProfitGrowthTargets" id="hcm_CappedCompensationPaymentUponGuaranteedProfitGrowthTargets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ShareOfNetAssetsDivestmentOfEquityMethodInvestment" id="hcm_ShareOfNetAssetsDivestmentOfEquityMethodInvestment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="OtherPayablesAccrualsAndAdvanceReceiptsDisclosureTextBlock" id="hcm_OtherPayablesAccrualsAndAdvanceReceiptsDisclosureTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ProvisionForProfitGuaranteeNonCurrentPortion" id="hcm_ProvisionForProfitGuaranteeNonCurrentPortion" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ProvisionForProfitGuaranteeCurrentPortion" id="hcm_ProvisionForProfitGuaranteeCurrentPortion" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ProvisionForProfitGuarantee" id="hcm_ProvisionForProfitGuarantee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DiscountingOnDividendPayment" id="hcm_DiscountingOnDividendPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ProvisionForProfitGuaranteeCurrentPortionAndNonCurrentPortion" id="hcm_ProvisionForProfitGuaranteeCurrentPortionAndNonCurrentPortion" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="InterestAccretionOnProvisionForProfitGuarantee" id="hcm_InterestAccretionOnProvisionForProfitGuarantee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="PresentProvisionForProfitGuaranteeCurrentPortionAndNonCurrentPortion" id="hcm_PresentProvisionForProfitGuaranteeCurrentPortionAndNonCurrentPortion" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="MirageneMember" id="hcm_MirageneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationDifferentialTaxRateToCapitalGainFromDivestmentAmount" id="hcm_EffectiveIncomeTaxRateReconciliationDifferentialTaxRateToCapitalGainFromDivestmentAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
</xsd:schema>
