v3.24.2
Document and Entity Information
6 Months Ended
Jun. 30, 2024
Document and Entity Information  
Document Type 6-K
Document Period End Date Jun. 30, 2024
Entity File Number 001-37710
Entity Registrant Name HUTCHMED (CHINA) LIMITED
Entity Address, Address Line One 48th Floor, Cheung Kong Center
Entity Address, Address Line Two 2 Queen’s Road Central
Entity Address, Country HK
Entity Central Index Key 0001648257
Current Fiscal Year End Date --12-31
Document Fiscal Year Focus 2024
Document Fiscal Period Focus Q2
Amendment Flag false
v3.24.2
CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($)
Jun. 30, 2024
Dec. 31, 2023
Current assets    
Cash and cash equivalents $ 203,953,000 $ 283,589,000
Short-term investments 598,500,000 602,747,000
Accounts receivable 156,916,000 116,894,000
Other receivables, prepayments and deposits 14,714,000 14,889,000
Amounts due from related parties $ 27,736,000 $ 28,462,000
Other Receivable, after Allowance for Credit Loss, Current, Related Party, Type [Extensible Enumeration] Related Parties [Member] Related Parties [Member]
Inventories $ 46,441,000 $ 50,258,000
Total current assets 1,048,260,000 1,096,839,000
Property, plant and equipment 94,815,000 99,727,000
Investment in an equity investee 80,519,000 48,411,000
Other non-current assets 37,274,000 34,796,000
Total assets 1,260,868,000 1,279,773,000
Current liabilities    
Accounts payable 43,398,000 36,327,000
Other payables, accruals and advance receipts 249,218,000 271,399,000
Short-term bank borrowings 26,468,000 31,155,000
Deferred revenue 48,152,000 57,639,000
Other current liabilities 6,052,000 6,507,000
Total current liabilities 373,288,000 403,027,000
Long-term bank borrowings 55,632,000 48,189,000
Deferred revenue, non-current portion 60,625,000 69,480,000
Other non-current liabilities 19,305,000 15,690,000
Total liabilities 508,850,000 536,386,000
Commitments and contingencies
Company's shareholders' equity    
Ordinary shares; $0.10 par value; 1,500,000,000 shares authorized; 871,359,720 shares and 871,256,270 shares issued at June 30, 2024 and December 31, 2023 respectively 87,136,000 87,126,000
Additional paid-in capital 1,507,550,000 1,522,447,000
Accumulated losses (845,068,000) (870,869,000)
Accumulated other comprehensive loss (9,534,000) (8,163,000)
Total Company's shareholders' equity 740,084,000 730,541,000
Non-controlling interests 11,934,000 12,846,000
Total shareholders' equity 752,018,000 743,387,000
Total liabilities and shareholders' equity $ 1,260,868,000 $ 1,279,773,000
v3.24.2
CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares
Jun. 30, 2024
Dec. 31, 2023
CONDENSED CONSOLIDATED BALANCE SHEETS    
Ordinary shares, par value (in US$ per share) $ 0.10 $ 0.10
Ordinary shares, authorized (in shares) 1,500,000,000 1,500,000,000
Ordinary shares, issued (in shares) 871,359,720 871,256,270
v3.24.2
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Revenue    
Total revenue $ 305,681 $ 532,874
Operating expenses    
Research and development expenses (95,256) (144,633)
Selling expenses (27,351) (26,423)
Administrative expenses (30,460) (41,840)
Total operating expenses (333,202) (421,220)
(Loss)/income from operations (27,521) 111,654
Other income, net 22,765 25,434
(Loss)/income before income taxes and equity in earnings of an equity investee (4,756) 137,088
Income tax expense (2,886) (2,730)
Equity in earnings of an equity investee, net of tax 33,807 35,110
Net income 26,165 169,468
Less: Net income attributable to non-controlling interests (364) (917)
Net income attributable to the Company $ 25,801 $ 168,551
Earnings per share attributable to the Company - basic (US$ per share) $ 0.03 $ 0.20
Earnings per share attributable to the Company - diluted (US$ per share) $ 0.03 $ 0.19
Number of shares used in per share calculation-basic (in shares) 856,030,704 846,928,863
Number of shares used in per share calculation-diluted (in shares) 872,534,466 866,990,610
Third parties    
Revenue    
Total revenue $ 303,443 $ 528,376
Related parties    
Revenue    
Total revenue 2,238 4,498
Goods | Third parties    
Revenue    
Total revenue 204,574 209,247
Operating expenses    
Cost of goods and services (151,681) (182,380)
Goods | Related parties    
Revenue    
Total revenue 2,002 4,252
Operating expenses    
Cost of goods and services (987) (2,536)
Services -commercialization    
Revenue    
Total revenue 28,222 25,359
Services -commercialization | Third parties    
Revenue    
Total revenue 28,222 25,359
Operating expenses    
Cost of goods and services (27,467) (23,408)
Services -collaboration research and development    
Revenue    
Total revenue 35,740 28,718
Services -collaboration research and development | Third parties    
Revenue    
Total revenue 35,740 28,718
Services -research and development    
Revenue    
Total revenue 236 246
Services -research and development | Related parties    
Revenue    
Total revenue 236 246
Other collaboration revenue -royalties    
Revenue    
Total revenue 34,907 14,982
Other collaboration revenue -royalties | Third parties    
Revenue    
Total revenue $ 34,907 14,982
Other collaboration revenue -licensing    
Revenue    
Total revenue   250,070
Other collaboration revenue -licensing | Third parties    
Revenue    
Total revenue   $ 250,070
v3.24.2
CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME    
Net income $ 26,165 $ 169,468
Other comprehensive loss    
Foreign currency translation loss (1,590) (6,245)
Total comprehensive income 24,575 163,223
Less: Comprehensive income attributable to non-controlling interests (145) (573)
Total comprehensive income attributable to the Company $ 24,430 $ 162,650
v3.24.2
CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS' EQUITY - USD ($)
shares in Thousands, $ in Thousands
Ordinary Shares
Additional Paid-in Capital
Accumulated Losses
Accumulated Other Comprehensive Loss
Total Company's Shareholders' Equity
Non-controlling Interests
Total
Balance at Dec. 31, 2022 $ 86,478 $ 1,497,273 $ (971,481) $ (1,903) $ 610,367 $ 26,503 $ 636,870
Balance (in shares) at Dec. 31, 2022 864,775            
Net income     168,551   168,551 917 169,468
Issuances in relation to share option exercises $ 138 920     1,058   1,058
Issuances in relation to share option exercises (in shares) 1,386            
Share-based compensation - Share options   3,236     3,236 3 3,239
Share-based compensation - Long-term incentive plan ("LTIP")   13,844     13,844 (33) 13,811
Share-based compensation   17,080     17,080 (30) 17,050
LTIP-treasury shares acquired and held by Trustee   (9,071)     (9,071)   (9,071)
Dividends declared to non-controlling shareholders of subsidiaries           (9,068) (9,068)
Transfer between reserves   127 (127)        
Divestment of an equity investee   (49)   4 (45)   (45)
Foreign currency translation adjustments       (5,901) (5,901) (344) (6,245)
Balance at Jun. 30, 2023 $ 86,616 1,506,280 (803,057) (7,800) 782,039 17,978 800,017
Balance (in shares) at Jun. 30, 2023 866,161            
Balance at Dec. 31, 2022 $ 86,478 1,497,273 (971,481) (1,903) 610,367 26,503 636,870
Balance (in shares) at Dec. 31, 2022 864,775            
Balance at Dec. 31, 2023 $ 87,126 1,522,447 (870,869) (8,163) 730,541 12,846 743,387
Balance (in shares) at Dec. 31, 2023 871,256            
Net income     25,801   25,801 364 26,165
Issuances in relation to share option exercises $ 10 218     228   228
Issuances in relation to share option exercises (in shares) 103            
Share-based compensation - Share options   1,429     1,429 3 1,432
Share-based compensation - Long-term incentive plan ("LTIP")   19,520     19,520 (60) 19,460
Share-based compensation   20,949     20,949 (57) 20,892
LTIP-treasury shares acquired and held by Trustee   (36,064)     (36,064)   (36,064)
Dividends declared to non-controlling shareholders of subsidiaries           (1,000) (1,000)
Foreign currency translation adjustments       (1,371) (1,371) (219) (1,590)
Balance at Jun. 30, 2024 $ 87,136 $ 1,507,550 $ (845,068) $ (9,534) $ 740,084 $ 11,934 $ 752,018
Balance (in shares) at Jun. 30, 2024 871,359            
v3.24.2
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS    
Net cash (used in)/generated from operating activities $ (39,832) $ 226,403
Investing activities    
Purchases of property, plant and equipment (10,108) (24,359)
Refund of leasehold land deposit 426  
Deposits in short-term investments (991,056) (835,092)
Proceeds from short-term investments 995,303 519,638
Dividends received from divestment of Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Company Limited   23,856
Net cash used in investing activities (5,435) (315,957)
Financing activities    
Proceeds from issuances of ordinary shares 228 1,058
Purchases of treasury shares (36,064) (9,071)
Dividends paid to non-controlling shareholders of subsidiaries (1,000) (9,068)
Proceeds from bank borrowings 8,466 22,911
Repayment of bank borrowings (4,192)  
Net cash (used in)/generated from financing activities (32,562) 5,830
Net decrease in cash and cash equivalents (77,829) (83,724)
Effect of exchange rate changes on cash and cash equivalents (1,807) (6,558)
Net decrease in cash and cash equivalents, including effect of exchange rate changes (79,636) (90,282)
Cash and cash equivalents    
Cash and cash equivalents at beginning of period 283,589 313,278
Cash and cash equivalents at end of period $ 203,953 $ 222,996
v3.24.2
Organization and Nature of Business
6 Months Ended
Jun. 30, 2024
Organization and Nature of Business  
Organization and Nature of Business

1.  Organization and Nature of Business

HUTCHMED (China) Limited (the “Company”) and its subsidiaries (together the “Group”) are principally engaged in researching, developing, manufacturing and marketing pharmaceutical products. The Group and its equity investee have research and development facilities and manufacturing plants in the People’s Republic of China (the “PRC”) and sell their products mainly in the PRC, including Hong Kong and Macau. In addition, the Group has established international operations in the United States of America (the “US”) and Europe.

The Company’s ordinary shares are listed on the Main Board of The Stock Exchange of Hong Kong Limited and the AIM market of the London Stock Exchange, and its American depositary shares (“ADS”) are traded on the Nasdaq Global Select Market.

Liquidity

As at June 30, 2024, the Group had accumulated losses of US$845,068,000 primarily due to its spending in drug research and development activities. The Group regularly monitors current and expected liquidity requirements to ensure that it maintains sufficient cash balances and adequate credit facilities to meet its liquidity requirements in the short and long term. As at June 30, 2024, the Group had cash and cash equivalents of US$203,953,000, short-term investments of US$598,500,000 and unutilized bank borrowing facilities of US$62,608,000. Short-term investments comprised of bank deposits maturing over three months.

Based on the Group’s operating plan, the existing cash and cash equivalents, short-term investments and unutilized bank borrowing facilities are considered to be sufficient to meet the cash requirements to fund planned operations and other commitments for at least the next twelve months from the issuance date of the interim unaudited condensed consolidated financial statements.

v3.24.2
Summary of Significant Accounting Policies
6 Months Ended
Jun. 30, 2024
Summary of Significant Accounting Policies  
Summary of Significant Accounting Policies

2.  Summary of Significant Accounting Policies

Basis of Presentation

The interim unaudited condensed consolidated financial statements have been prepared in conformity with generally accepted accounting principles in the United States of America (“US GAAP”) for interim financial information. Accordingly, they do not include all of the information and footnotes required by US GAAP for complete financial statements. The interim unaudited condensed consolidated financial statements have been prepared on the same basis as the annual audited consolidated financial statements. In the opinion of management, all adjustments, consisting of normal recurring adjustments necessary for the fair statement of results for the periods presented, have been included. The results of operations of any interim period are not necessarily indicative of the results of operations for the full year or any other interim period.

The comparative year-end condensed balance sheet data was derived from the annual audited consolidated financial statements, but is condensed to the same degree as the interim condensed balance sheet data.

The interim unaudited condensed consolidated financial statements and related disclosures have been prepared with the presumption that users have read or have access to the annual audited consolidated financial statements for the preceding fiscal year.

The preparation of interim unaudited condensed consolidated financial statements in conformity with US GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the interim unaudited condensed consolidated financial statements and the reported amounts of revenue and expenses during the reporting period.

Recent Accounting Pronouncements

Amendments that have been issued by the Financial Accounting Standards Board or other standard-setting bodies that do not require adoption until a future date are not expected to have a material impact on the Group’s condensed consolidated financial statements.

v3.24.2
Cash and Cash Equivalents and Short-term Investments
6 Months Ended
Jun. 30, 2024
Cash and Cash Equivalents and Short-term Investments  
Cash and Cash Equivalents and Short-term Investments

3.  Cash and Cash Equivalents and Short-term Investments

June 30, 

December 31,

    

2024

    

2023

(in US$000)

Cash and Cash Equivalents

Cash at bank and on hand

105,995

129,968

Bank deposits maturing in three months or less

97,958

153,621

203,953

283,589

Short-term Investments

Bank deposits maturing over three months (note)

598,500

602,747

802,453

886,336

Note: The maturities for short-term investments ranged from 91 to 186 days and 91 to 187 days for the six months ended June 30, 2024 and the year ended December 31, 2023 respectively.

Certain cash and bank balances denominated in Renminbi (“RMB”), US dollar (“US$”) and UK Pound Sterling (“£”) were deposited with banks in the PRC. The conversion of these balances into foreign currencies is subject to the rules and regulations of foreign exchange control promulgated by the PRC government. Cash and cash equivalents and short-term investments were denominated in the following currencies:

    

June 30,

    

December 31,

2024

2023

(in US$000)

US$

744,276

836,718

RMB

52,782

45,772

Hong Kong dollar (“HK$”)

4,870

3,114

£

446

713

Others

79

19

802,453

886,336

v3.24.2
Accounts Receivable
6 Months Ended
Jun. 30, 2024
Accounts Receivable  
Accounts Receivable

4.  Accounts Receivable

Accounts receivable from contracts with customers consisted of the following:

June 30,

December 31, 

    

2024

    

2023

(in US$000)

Accounts receivable—third parties

156,931

115,169

Accounts receivable—a related party (Note 15(ii))

10

1,896

Allowance for credit losses

(25)

(171)

Accounts receivable, net

156,916

116,894

Substantially all accounts receivable are denominated in RMB, US$ and HK$ and are due within one year from the end of the reporting period. The carrying values of accounts receivable approximate their fair values due to their short-term maturities.

An aging analysis for accounts receivable—third parties based on the relevant invoice dates is as follows:

    

June 30, 

    

December 31, 

2024

2023

(in US$000)

Not later than 3 months

 

138,947

96,057

Between 3 months to 6 months

 

12,165

11,507

Between 6 months to 1 year

 

4,720

6,439

Later than 1 year

 

1,099

1,166

Accounts receivable—third parties

 

156,931

115,169

Movements on the allowance for credit losses:

    

2024

    

2023

 

(in US$000)

As at January 1

171

60

Increase in allowance for credit losses

25

150

Decrease in allowance due to subsequent collection

(168)

(17)

Exchange difference

(3)

(4)

As at June 30

25

189

v3.24.2
Other Receivables, Prepayments and Deposits
6 Months Ended
Jun. 30, 2024
Other Receivables, Prepayments and Deposits  
Other Receivables, Prepayments and Deposits

5.  Other Receivables, Prepayments and Deposits

Other receivables, prepayments and deposits consisted of the following:

June 30, 

December 31, 

    

2024

    

2023

(in US$000)

Prepayments

7,082

7,108

Interest receivables

 

2,842

2,936

Deposits

1,057

1,065

Value-added tax receivables

363

2,166

Others

 

3,370

1,614

 

14,714

14,889

No allowance for credit losses has been made for other receivables, prepayments and deposits for the six months ended June 30, 2024 and the year ended December 31, 2023.

v3.24.2
Inventories
6 Months Ended
Jun. 30, 2024
Inventories  
Inventories

6.  Inventories

Inventories, net of provision for excess and obsolete inventories, consisted of the following:

 

June 30, 

December 31, 

    

2024

    

2023

 

(in US$000)

Raw materials

24,794

26,784

Finished goods

21,647

23,474

46,441

50,258

v3.24.2
Investment in an Equity Investee
6 Months Ended
Jun. 30, 2024
Investment in an Equity Investee  
Investments in an Equity Investee

7.  Investment in an Equity Investee

Investment in an equity investee consisted of the following:

 

June 30, 

December 31, 

    

2024

    

2023

 

(in US$000)

Shanghai Hutchison Pharmaceuticals Limited (“SHPL”)

80,519

48,411

The equity investee is a private company and there is no quoted market price available for its equity.

Summarized financial information for SHPL is as follows:

(i)

Summarized balance sheets

 

June 30, 

December 31, 

    

2024

    

2023

 

(in US$000)

Current assets

237,504

201,025

Non-current assets

69,310

73,939

Current liabilities

(146,504)

(179,649)

Non-current liabilities

(4,026)

(3,687)

Net assets

156,284

91,628

(ii)

Summarized statements of operations

Six Months Ended June 30,

    

2024

    

2023

(in US$000)

Revenue

 

225,208

235,271

Gross profit

 

166,758

175,750

Interest income

 

338

438

Finance cost (note (a))

 

(1,022)

Profit before taxation

80,213

84,064

Income tax expense (note (b))

(12,294)

(13,840)

Net income (note (c))

 

67,919

70,224

Notes:

(a)

Finance cost was from the accretion of the discount recorded on the dividends payable.

(b)

The main entity within the SHPL group has been granted the High and New Technology Enterprise status (the latest renewal of this status covers the years from 2023 to 2025). Accordingly, the entity was eligible to use a preferential income tax rate of 15% for the six months ended June 30, 2024 and 2023.

(c)

Net income is before elimination of unrealized profits on transactions with the Group. The amounts eliminated were approximately US$152,000 and US$2,000 for the six months ended June 30, 2024 and 2023 respectively.

(iii)

Reconciliation of summarized financial information

Reconciliation of the summarized financial information presented to the carrying amount of investment in an equity investee is as follows:

    

2024

    

2023

 

(in US$000)

Opening net assets as at January 1

91,628

141,433

Net income

67,919

70,224

Dividends declared

(146,974)

Deemed distribution

(690)

Discount on dividends payable

3,654

Other comprehensive (loss)/income

(2,573)

1,785

Closing net assets as at June 30

156,284

70,122

Group’s share of net assets

78,142

35,061

Goodwill

2,744

2,795

Elimination of unrealized profits on downstream sales

(367)

(116)

Carrying amount of investment as at June 30

80,519

37,740

SHPL had the following capital commitments:

 

June 30, 

    

2024

 

(in US$000)

Property, plant and equipment

Contracted but not provided for

1,361

v3.24.2
Accounts Payable
6 Months Ended
Jun. 30, 2024
Accounts Payable  
Accounts Payable

8.  Accounts Payable

    

June 30, 

    

December 31, 

2024

2023

(in US$000)

Accounts payable

 

43,398

36,327

Substantially all accounts payable are denominated in RMB and US$ and due within one year from the end of the reporting period. The carrying values of accounts payable approximate their fair values due to their short-term maturities.

An aging analysis based on the relevant invoice dates is as follows:

    

June 30, 

    

December 31, 

2024

2023

(in US$000)

Not later than 3 months

 

37,817

33,233

Between 3 months to 6 months

 

3,446

1,058

Between 6 months to 1 year

 

1,018

941

Later than 1 year

 

1,117

1,095

43,398

36,327

v3.24.2
Other Payables, Accruals and Advance Receipts
6 Months Ended
Jun. 30, 2024
Other Payables, Accruals and Advance Receipts  
Other Payables, Accruals and Advance Receipts

9.  Other Payables, Accruals and Advance Receipts

Other payables, accruals and advance receipts consisted of the following:

 

June 30, 

December 31, 

    

2024

    

2023

 

(in US$000)

Accrued research and development expenses

142,667

153,737

Accrued salaries and benefits

26,249

45,048

Accrued selling and marketing expenses

17,930

16,340

Accrued capital expenditures

16,368

23,659

Accrued administrative and other general expenses

15,737

15,777

Advances for inventory purchases

6,076

1,896

Value-added tax payables

3,146

121

Amounts due to related parties (Note 15(ii))

2,150

2,162

Deposits

1,633

1,564

Deferred government grants

635

740

Others

16,627

10,355

249,218

271,399

v3.24.2
Bank Borrowings
6 Months Ended
Jun. 30, 2024
Bank Borrowings  
Bank Borrowings

10.  Bank Borrowings

Bank borrowings consisted of the following:

 

June 30, 

December 31, 

     

2024

     

2023

 

(in US$000)

Current

26,468

31,155

Non-current

55,632

48,189

82,100

79,344

The weighted average interest rate for outstanding bank borrowings for the six months ended June 30, 2024 and the year ended December 31, 2023 was 3.09% per annum and 3.41% per annum respectively. The carrying amounts of the Group’s outstanding bank borrowings as at June 30, 2024 and December 31, 2023 were denominated in RMB.

(i)  Short-term working capital loan facility

In November 2023, a subsidiary entered into a short-term working capital loan facility with a bank in the amount of RMB300,000,000 (US$41,154,000) with an annual interest rate at the 1-year China Loan Prime Rate (“LPR”) less 0.95%. As at June 30, 2024 and December 31, 2023, RMB192,941,000 (US$26,468,000) and RMB222,941,000 (US$31,155,000) were drawn from the facility respectively.

(ii)  10-year fixed asset loan facility

In October 2021, a subsidiary entered into a 10-year fixed asset loan facility agreement with the bank for the provision of a secured credit facility in the amount of RMB754,880,000 (US$103,554,000) with an annual interest rate at the 5-year China LPR less 0.8% (which was supplemented in June 2022) and interest payments commencing upon completion of construction of the underlying buildings. This credit facility is guaranteed by the immediate holding company of the subsidiary and secured by the underlying leasehold land and buildings. As at June 30, 2024 and December 31, 2023, RMB405,542,000 (US$55,632,000) and RMB344,840,000 (US$48,189,000) were utilized from the fixed asset loan facility respectively.

For the six months ended June 30, 2024 and the year ended December 31, 2023, nil and US$1,047,000 were related to capitalized interest.

The Group’s bank borrowings are repayable as from the dates indicated as follows:

 

June 30, 

December 31, 

    

2024

    

2023

 

(in US$000)

Not later than 1 year

26,468

31,155

Between 1 to 3 years

5,159

3,192

Between 3 to 4 years

3,685

2,872

Between 4 to 5 years

11,054

6,384

Later than 5 years

35,734

35,741

82,100

79,344

As at June 30, 2024 and December 31, 2023, the Group had unutilized bank borrowing facilities of US$62,608,000 and US$68,069,000 respectively.

v3.24.2
Commitments and Contingencies
6 Months Ended
Jun. 30, 2024
Commitments and Contingencies  
Commitments and Contingencies

11.  Commitments and Contingencies

The Group had the following capital commitments:

 

June 30,

    

2024

 

(in US$000)

Property, plant and equipment

Contracted but not provided for

1,613

The Group does not have any other significant commitments or contingencies.

v3.24.2
Share-based Compensation
6 Months Ended
Jun. 30, 2024
Share-based Compensation  
Share-based Compensation

12.  Share-based Compensation

(i)   Share-based Compensation of the Company

The Company conditionally adopted a share option scheme on April 24, 2015 (as amended on April 27, 2020) (the “Share Option Scheme”). Pursuant to the Share Option Scheme, the Board of Directors of the Company may, at its discretion, offer any employees and directors (including Executive and Non-executive Directors but excluding Independent Non-executive Directors) of the Company, holding companies of the Company and any of their subsidiaries or affiliates, and subsidiaries or affiliates of the Company share options to subscribe for shares of the Company.

As at June 30, 2024, the aggregate number of shares issuable under the Share Option Scheme was 41,977,648 ordinary shares. The Company will issue new shares to satisfy share option exercises. Additionally, the number of shares authorized but unissued was 628,640,280 ordinary shares.

Share options granted are generally subject to a four-year vesting schedule, depending on the nature and the purpose of the grant. Share options subject to the four-year vesting schedule, in general, vest 25% upon the first anniversary of the vesting commencement date as defined in the grant letter, and 25% every subsequent year. However, certain share option grants may have a different vesting schedule as approved by the Board of Directors of the Company. No outstanding share options will be exercisable or subject to vesting after the expiry of a maximum of ten years from the date of grant.

A summary of the Company’s share option activity and related information is as follows:

Weighted average

Number of

Weighted average

remaining

Aggregate

share

exercise price in

contractual life

intrinsic value

    

options

    

 US$ per share

    

(years)

    

(in US$000)

Outstanding at January 1, 2023

39,521,395

4.34

6.55

11,525

Granted

1,221,900

2.50

Exercised

(6,480,930)

2.30

Cancelled

(2,832,340)

4.61

Expired

(1,893,370)

5.55

Outstanding at December 31, 2023

29,536,655

4.57

6.67

9,924

Granted (note)

1,359,561

3.63

Exercised

(103,450)

2.20

Cancelled

(661,800)

4.63

Expired

(826,925)

5.41

Outstanding at June 30, 2024

29,304,041

4.50

6.30

7,910

Vested and exercisable at December 31, 2023

18,198,170

5.10

5.91

1,753

Vested and exercisable at June 30, 2024

21,511,195

4.93

5.61

2,728

Note: This was granted to an executive director in March 2024 where the number of share options exercisable is subject to certain performance targets based on a market condition covering the 3-year period from 2023 to 2025 which has been reflected in estimating the grant date fair value. The grant date fair value of such award is US$1.29 per share using the Monte Carlo simulation model. Vesting of such award will occur in March 2026 if the performance targets are met.

In estimating the fair value of share options granted, the following assumptions were used in the Monte Carlo simulation model for the award granted during the six months ended June 30, 2024 and Polynomial model for the award granted during the year ended December 31, 2023:

Six Months Ended

Year Ended

 

    

June 30, 2024

    

December 31, 2023

Weighted average grant date fair value of share options (in US$ per share)

 

1.29

1.14

Significant inputs into the valuation model (weighted average):

 

Exercise price (in US$ per share)

 

3.63

2.50

Share price at effective date of grant (in US$ per share)

 

3.63

2.50

Expected volatility (note (a))

 

54.3

%

53.3

%

Risk-free interest rate (note (b))

 

4.15

%

3.69

%

Contractual life of share options (in years)

 

10

10

Expected dividend yield (note (c))

 

0

%

0

%

Notes:

(a)

The Company calculated its expected volatility with reference to the historical volatility prior to the issuances of share options.

(b)

The risk-free interest rates reference the US Treasury yield curves.

(c)

The Company has not declared or paid any dividends and does not currently expect to do so prior to the exercise of the granted share options, and therefore uses an expected dividend yield of zero in the valuation models.

The Company will issue new shares to satisfy share option exercises. The following table summarizes the Company’s share option exercises:

    

Six Months Ended June 30, 

    

2024

    

2023

(in US$000)

Cash received from share option exercises

228

1,058

Total intrinsic value of share option exercises

161

1,898

The Group recognizes compensation expense on a graded vesting approach over the requisite service period. The following table presents share-based compensation expense included in the Group’s condensed consolidated statements of operations:

 

Six Months Ended June 30, 

    

2024

    

2023

 

(in US$000)

Research and development expenses

801

1,664

Selling and administrative expenses

597

1,522

Cost of revenue

34

53

1,432

3,239

As at June 30, 2024, the total unrecognized compensation cost was US$4,078,000 and will be recognized on a graded vesting approach over the weighted average remaining service period of 1.80 years.

(ii)   LTIP

The Company grants awards under the LTIP to participating directors and employees, giving them a conditional right to receive ordinary shares of the Company or the equivalent ADS (collectively the “Awarded Shares”) to be purchased by the Trustee up to a cash amount excluding any cash elected payments. Vesting will depend upon continued employment of the award holder with the Group and will otherwise be at the discretion of the Board of Directors of the Company. Additionally, some awards are subject to change based on annual performance targets prior to their determination date.

LTIP awards prior to the determination date

Performance targets vary by award, and may include targets for shareholder returns, financings, revenue, net income/(loss) after taxes and the achievement of clinical, regulatory, business development and manufacturing milestones. As the extent of achievement of the performance targets is uncertain prior to the determination date, a probability based on management’s assessment on the achievement of the performance target has been assigned to calculate the amount to be recognized as an expense over the requisite period with a corresponding entry to liability.

LTIP awards after the determination date

Upon the determination date, based on the actual achievement of performance target, the amount previously recorded in the liability will be adjusted through share-based compensation expense. The Company will pay a determined monetary amount, up to the maximum cash amount based on the actual achievement of the performance target specified in the award, to the Trustee to purchase the Awarded Shares. Any cumulative compensation expense previously recognized as a liability will be transferred to additional paid-in capital.

Granted awards under the LTIP are as follows:

    

Maximum cash

    

    

amount

Covered

Performance target

Grant date

(in US$ millions)

financial years

determination date

June 5, 2023

54.9

2023

note (a)

March 13, 2024

0.7

note (b)

note (b)

Notes:

(a)

The annual performance target determination date is the date of the announcement of the Group’s annual results for the covered financial year and vesting occurs two business days after the announcement of the Group’s annual results for the financial year falling two years after the covered financial year to which the LTIP award relates.

(b)

This award does not stipulate performance targets and is subject to a vesting schedule of 25% on each of the first, second, third and fourth anniversaries of the date of grant.

The Trustee has been set up solely for the purpose of purchasing and holding the Awarded Shares during the vesting period on behalf of the Company using funds provided by the Company. On the determination date, if any, the Company will determine the cash amount, based on the actual achievement of each annual performance target, for the Trustee to purchase the Awarded Shares. The Awarded Shares will then be held by the Trustee until they are vested.

The Trustee’s assets include treasury shares and funds for additional treasury shares, trustee fees and expenses. The number of treasury shares (in ordinary shares equivalent) held by the Trustee were as follows:

Number of

Cost

    

treasury shares

    

(in US$000)

As at January 1, 2023

19,601,375

76,064

Purchased

2,725,515

9,071

Vested

(4,714,205)

(18,148)

As at December 31, 2023

17,612,685

66,987

Purchased

10,259,133

36,064

Vested

(10,952,145)

(41,371)

As at June 30, 2024

16,919,673

61,680

For the six months ended June 30, 2024 and 2023, US$8,574,000 and US$5,041,000 of the LTIP awards were forfeited respectively based on the determined or estimated monetary amount as at the forfeiture date.

The following table presents the share-based compensation expense recognized under the LTIP awards:

Six Months Ended June 30, 

    

2024

    

2023

(in US$000)

Research and development expenses

 

6,398

5,700

Selling and administrative expenses

 

3,203

4,614

Cost of revenue

279

237

9,880

10,551

Recorded with a corresponding credit to:

Liability

2,844

1,303

Additional paid-in capital

7,036

9,248

 

9,880

10,551

For the six months ended June 30, 2024 and 2023, US$12,424,000 and US$4,563,000 were reclassified from liability to additional paid-in capital respectively upon LTIP awards reaching the determination date. As at June 30, 2024 and December 31, 2023, US$577,000 and US$10,502,000 were recorded in liabilities respectively.

As at June 30, 2024, the total unrecognized compensation cost was approximately US$30,121,000, which considers expected performance targets and the amounts expected to vest, and will be recognized over the requisite periods.

v3.24.2
Revenue
6 Months Ended
Jun. 30, 2024
Revenue  
Revenue

13.  Revenue

The following table presents revenue disaggregated by contract type:

Six Months Ended June 30, 2024

    

Oncology/

    

    

Immunology

Other Ventures

Total

(in US$000)

Invoiced Goods—Marketed Products

 

64,667

64,667

 —Distribution

 

137,044

137,044

Services—Commercialization of Marketed Products

 

28,222

28,222

Research and Development

236

236

License & Collaborations—Services

35,740

35,740

 Royalties

34,907

34,907

 Manufacturing supply

4,865

4,865

 

168,637

137,044

305,681

 

Third parties

 

168,401

135,042

303,443

Related parties (Note 15(i))

 

236

2,002

2,238

168,637

137,044

305,681

Six Months Ended June 30, 2023

Oncology/

    

    

    

Immunology

Other Ventures

Total

(in US$000)

Invoiced Goods—Marketed Products

 

39,808

39,808

 —Distribution

173,691

173,691

Services—Commercialization of Marketed Products

 

25,359

25,359

Research and Development

246

246

License & Collaborations—Services

 

28,718

28,718

 Royalties

14,982

14,982

 Licensing

250,070

250,070

359,183

173,691

532,874

Third parties

 

358,937

169,439

528,376

Related parties (Note 15(i))

 

246

4,252

4,498

359,183

173,691

532,874

The following table presents liability balances from contracts with customers:

    

June 30,

    

December 31,

2024

2023

(in US$000)

Deferred revenue

 

  

 

  

Current—Oncology/Immunology segment (note (a))

 

48,100

57,566

Current—Other Ventures segment (note (b))

 

52

73

 

48,152

57,639

Non-current—Oncology/Immunology segment (note (a))

 

60,625

69,480

Total deferred revenue (note (c) and (d))

 

108,777

127,119

Notes:

(a)

Oncology/Immunology segment deferred revenue relates to unamortized upfront and milestone payments, invoiced amounts for royalties where the customer has not yet completed the in-market sale and other advance consideration received.

(b)

Other Ventures segment deferred revenue relates to payments in advance from customers for goods that have not been transferred and services that have not been rendered to the customer as at the reporting date.

(c)

Estimated deferred revenue to be recognized over time as from the date indicated is as follows:

    

June 30,

    

December 31,

2024

2023

(in US$000)

Not later than 1 year

 

48,152

57,639

Between 1 to 2 years

 

33,502

32,797

Between 2 to 3 years

 

21,418

30,918

Between 3 to 4 years

 

1,169

844

Later than 4 years

 

4,536

4,921

 

108,777

127,119

(d)

As at January 1, 2024, deferred revenue was US$127.1 million, of which US$26.3 million was recognized during the six months ended June 30, 2024.

License and collaboration agreement with Takeda Pharmaceuticals

On January 23, 2023, the Group and Takeda Pharmaceuticals International AG (“Takeda”) entered into an exclusive out-licensing agreement (the “Takeda Agreement”) in territories outside of Mainland China, Hong Kong and Macau (the “Territory”) to further the global development, commercialization and manufacturing of Fruzaqla, also known as fruquintinib, a targeted oncology therapy for the treatment of various types of solid tumors. Under the terms of the Takeda Agreement, the Group is entitled to receive a series of payments up to US$1.13 billion, including upfront, regulatory, development and commercial sales milestone payments, plus royalties on net sales in the Territory. Fruzaqla was successfully approved for commercialization in the US in November 2023, which triggered a regulatory approval milestone of US$35 million.

Upfront and milestone payments according to the Takeda Agreement received up to June 30, 2024 are summarized as follows:

    

(in US$000)

Upfront payment

 

400,000

Regulatory approval milestone payment achieved

 

35,000

Note: As of June 30, 2024, US$298.1 million of the upfront payment and US$33.3 million of the regulatory approval milestone payment were recognized as revenue, including $18.1 million and $1.3 million respectively during the six months ended June 30, 2024.

The Takeda Agreement has the following material performance obligations: (1) the licenses for the development and commercialization of Fruzaqla in the Territory and the manufacture of Fruzaqla for use in the Territory, (2) manufacturing supply and (3) services for research and development including ongoing clinical trials and regulatory submissions and manufacturing technology transfer.

The transaction price for these performance obligations includes the upfront payment, service cost reimbursements, milestone payments and sales-based royalties. Milestone payments are not included in the transaction price until they become probable that a significant reversal of revenue would not occur, which is generally when the criteria to receive the specified milestone are achieved.

The allocation of the transaction price to each relevant performance obligation was based on the relative standalone selling price of each performance obligation determined at the inception of the contract. Variable consideration is allocated entirely to a performance obligation or to a distinct good or service that forms part of a single performance obligation if the terms of the variable consideration relate to the satisfaction of the respective performance obligation and the amount allocated is consistent with the amount expected to be received for the satisfaction of the respective performance obligation. The standalone selling price of the licenses for the development and commercialization of Fruzaqla in the Territory and the manufacture of Fruzaqla for use in the Territory and manufacturing supply was determined using a discounted cash flow method based on the probability-weighted present value of forecasted cash flows associated with out-licensing Fruzaqla in the Territory, and the standalone selling price of the services for research and development of ongoing clinical trials, regulatory submissions and manufacturing technology transfer was determined using a cost plus margin approach based on the present value of estimated future service costs plus a reasonable margin. Significant assumptions included in the determination of the standalone selling prices for each performance obligation identified including forecasted revenue, probabilities of regulatory approvals, estimated future service costs, margin rates and discount rates. Based on these estimations, proportionate amounts of transaction price to be allocated to the licenses, and other performance obligations were 62% and 38% respectively at contract inception. Control of the licenses to Fruzaqla was transferred at the inception date of the agreement and consequently, amounts allocated to this performance obligation were recognized at inception. Manufacturing supply is recognized at a point in time when the control of the goods is transferred. Services are performed over the term of the Takeda Agreement and amounts allocated are recognized over time using a percentage-of-completion method. Royalties are recognized as future sales occur as they meet the requirements for the sales-usage based royalty exception.

Revenue recognized under the Takeda Agreement is as follows:

Six Months Ended June 30,

    

2024

    

2023

(in US$000)

Manufacturing supply—Invoiced Marketed Products sales

 

24,806

—Allocated from upfront payment

4,865

Services—Research and Development

14,389

10,372

—Allocated from upfront and milestone payments

14,524

8,615

Royalties—Marketed Products

18,028

Licensing—Allocated from upfront and milestone payments

250,070

 

76,612

269,057

v3.24.2
Research and Development Expenses
6 Months Ended
Jun. 30, 2024
Research and Development Expenses  
Research and Development Expenses

14.  Research and Development Expenses

Research and development expenses are summarized as follows:

Six Months Ended June 30, 

    

2024

    

2023

 

(in US$000)

Clinical trial related costs

55,728

94,909

Personnel compensation and related costs

36,858

45,410

Other research and development expenses

2,670

4,314

95,256

144,633

The Group has entered into multiple collaborative arrangements under ASC 808 to evaluate the combination of the Group’s drug compounds with the collaboration partners’ drug compounds. For the six months ended June 30, 2024 and 2023, the Group has incurred research and development expenses of US$4.1 million and US$8.1 million respectively, related to such collaborative arrangements.

v3.24.2
Significant Transactions with Related Parties and Non-Controlling Shareholders of Subsidiaries
6 Months Ended
Jun. 30, 2024
Significant Transactions with Related Parties and Non-Controlling Shareholders of Subsidiaries  
Significant Transactions with Related Parties and Non-Controlling Shareholders of Subsidiaries

15.  Significant Transactions with Related Parties and Non-Controlling Shareholders of Subsidiaries

The Group has the following significant transactions with related parties and non-controlling shareholders of subsidiaries, which were carried out in the normal course of business at terms determined and agreed by the relevant parties:

(i)

Transactions with related parties:

Six Months Ended June 30, 

    

2024

    

2023

 

(in US$000)

Sales to:

Indirect subsidiaries of CK Hutchison Holdings Limited (“CK Hutchison”)

4

1,008

An equity investee

1,998

3,244

2,002

4,252

Revenue from research and development services from:

An equity investee

236

246

Purchase from:

An equity investee

1,452

1,911

Rendering of marketing services from:

Indirect subsidiaries of CK Hutchison

59

Rendering of management services from:

An indirect subsidiary of CK Hutchison

535

498

(ii)

Balances with related parties included in:

June 30, 

December 31, 

    

2024

    

2023

 

(in US$000)

Accounts receivable—a related party

An equity investee (note (a))

10

1,896

Amounts due from related parties

An indirect subsidiary of CK Hutchison (note (a))

228

An equity investee (note (a) and (b))

27,736

28,234

27,736

28,462

Other payables, accruals and advance receipts

Indirect subsidiaries of CK Hutchison (note (c) and (e))

1,870

2,017

An equity investee (note (a) and (d))

280

145

2,150

2,162

Other non-current liabilities

An equity investee (note (d))

179

450

An indirect subsidiary of CK Hutchison (note (e))

7,820

7,619

7,999

8,069

Notes:

(a)

Balances with related parties are unsecured, repayable on demand and interest-free. The carrying values of balances with related parties approximate their fair values due to their short-term maturities. No allowance for credit losses has been made for amounts due from related parties for the six months ended June 30, 2024 and the year ended December 31, 2023.

(b)

As at June 30, 2024 and December 31, 2023, dividends receivable of US$26,632,000 and US$27,130,000 was included in amounts due from related parties.

(c)

Amounts due to indirect subsidiaries of CK Hutchison are unsecured, repayable on demand and interest-bearing if not settled within one month.

(d)

Includes other deferred income representing amounts recognized from granting of commercial, promotion and marketing rights.

(e)

As at June 30, 2024 and December 31, 2023, a branding liability payable of US$1,538,000 was included in amounts due to related parties under other payables, accruals and advance receipts. As at June 30, 2024 and December 31, 2023, US$7,820,000 and US$7,619,000 of the branding liability payable was included in other non-current liabilities.

(iii)

Transactions with non-controlling shareholders of subsidiaries:

Six Months Ended June 30, 

    

2024

    

2023

(in US$000)

Sales

 

29,395

35,933

Purchases

 

127

3,199

Dividends declared

 

1,000

9,068

Distribution service

108

(iv)

Balances with non-controlling shareholders of subsidiaries included in:

    

June 30, 

    

December 31, 

2024

2023

(in US$000)

Accounts receivable

 

8,750

7,824

Accounts payable

 

92

27

Other payables, accruals and advance receipts

 

324

309

v3.24.2
Income Taxes
6 Months Ended
Jun. 30, 2024
Income Taxes  
Income Taxes

16.  Income Taxes

(i)

Income tax expense

Six Months Ended June 30, 

    

2024

    

2023

(in US$000)

Current tax

HK

1

6

PRC

868

976

US and others

86

52

Total current tax

955

1,034

Deferred income tax expense

1,931

1,696

Income tax expense

2,886

2,730

The reconciliation of the Group’s reported income tax expense to the theoretical tax amount that would arise using the tax rates of the Company against the Group’s (loss)/income before income taxes and equity in earnings of an equity investee is as follows:

Six Months Ended June 30, 

    

2024

    

2023

 

(in US$000)

(Loss)/income before income taxes and equity in earnings of an equity investee

(4,756)

137,088

Tax calculated at the statutory tax rate of the Company

(785)

22,620

Tax effects of:

Different tax rates applicable in different jurisdictions

625

(1,423)

Tax valuation allowance

6,513

(2,898)

Preferential tax rate difference

(32)

(39)

Preferential tax deduction and credits

(8,405)

(17,735)

Expenses not deductible for tax purposes

7,548

2,829

Utilization of previously unrecognized tax losses

(3)

(39)

Withholding tax on undistributed earnings of PRC entities

1,670

1,755

Income not subject to tax

(2,852)

(2,478)

Temporary difference

(1,615)

(127)

Others

222

265

Income tax expense

2,886

2,730

v3.24.2
Earnings Per Share
6 Months Ended
Jun. 30, 2024
Earnings Per Share  
Earnings Per Share

17.  Earnings Per Share

(i)   Basic earnings per share

Basic earnings per share is calculated by dividing the net income attributable to the Company by the weighted average number of outstanding ordinary shares in issue during the period. Treasury shares held by the Trustee are excluded from the weighted average number of outstanding ordinary shares in issue for purposes of calculating basic earnings per share.

Six Months Ended June 30, 

    

2024

    

2023

Weighted average number of outstanding ordinary shares in issue

 

856,030,704

846,928,863

Net income attributable to the Company (US$’000)

 

25,801

168,551

Basic earnings per share attributable to the Company (US$ per share)

 

0.03

0.20

(ii)  Diluted earnings per share

Diluted earnings per share is calculated by dividing net income attributable to the Company by the weighted average number of outstanding ordinary shares in issue and dilutive ordinary share equivalents outstanding during the period. Dilutive ordinary share equivalents include shares issuable upon the exercise or settlement of share options and LTIP awards issued by the Company using the treasury stock method.

Six Months Ended June 30,

    

2024

    

2023

Weighted average number of outstanding ordinary shares in issue

 

856,030,704

 

846,928,863

Effect of share options and LTIP awards

 

16,503,762

 

20,061,747

Weighted average number of outstanding ordinary shares in issue and dilutive ordinary share equivalents outstanding

 

872,534,466

 

866,990,610

Net income attributable to the Company (US$’000)

 

25,801

 

168,551

Diluted earnings per share attributable to the Company (US$ per share)

 

0.03

 

0.19

v3.24.2
Segment Reporting
6 Months Ended
Jun. 30, 2024
Segment Reporting  
Segment Reporting

18.  Segment Reporting

The Group’s operating segments are as follows:

(i)

Oncology/Immunology: focuses on discovering, developing, and commercializing targeted therapies and immunotherapies for the treatment of cancer and immunological diseases. Oncology/Immunology is further segregated into two core business areas:

(a)

R&D: comprises research and development activities covering drug discovery, development, manufacturing and regulatory functions, out-licensing of in-house developed drugs, as well as administrative activities to support research and development operations; and

(b)

Marketed Products: comprises the invoiced sales, marketing, manufacture and distribution of drugs developed from research and development activities including out-licensed marketed products.

(ii)

Other Ventures: comprises other commercial businesses which include the sales, marketing, manufacture and distribution of other prescription drugs and healthcare products.

The performance of the reportable segments is assessed based on segment net (loss)/income attributable to the Company.

The segment information is as follows:

 

Six Months Ended June 30, 2024

Oncology/Immunology

Other

R&D

Marketed Products

Ventures

 

US and

US and

  

  

    

PRC

    

Others

    

Subtotal

    

PRC

    

Others

    

Subtotal

    

Subtotal

    

PRC

    

Unallocated

    

Total

 

(in US$000)

Revenue from external customers

7,063

33,778

40,841

84,962

42,834

127,796

168,637

137,044

305,681

Interest income

417

1

418

418

116

20,040

20,574

Interest expense

(914)

(914)

(914)

(362)

(200)

(1,476)

Equity in earnings of an equity investee, net of tax

33,807

33,807

Income tax expense

(100)

(479)

(579)

(530)

(530)

(1,109)

(97)

(1,680)

(2,886)

Net (loss)/income attributable to the Company

(84,530)

16,693

(67,837)

14,771

38,424

53,195

(14,642)

34,149

6,294

25,801

Depreciation/ amortization

(5,937)

(139)

(6,076)

(6,076)

(130)

(46)

(6,252)

Additions to non-current assets (other than financial instruments and deferred tax assets)

3,763

3,763

3,763

1,929

1,234

6,926

 

June 30, 2024

Oncology/Immunology

Other

R&D

Marketed Products

Ventures

 

   

US and

   

  

US and

  

    

PRC

    

Others

    

Subtotal

    

PRC

    

Others

    

Subtotal

    

Subtotal

    

PRC

    

Unallocated

    

Total

 

(in US$000)

Total assets

178,012

30,377

208,389

69,807

38,944

108,751

317,140

193,885

749,843

1,260,868

Property, plant and equipment

93,375

777

94,152

94,152

498

165

94,815

Right-of-use assets

2,813

481

3,294

3,294

1,858

1,240

6,392

Leasehold land

10,931

10,931

10,931

10,931

Goodwill

3,015

3,015

Investment in an equity investee

80,519

80,519

 

Six Months Ended June 30, 2023

 

Oncology/Immunology

 

Other

 

R&D

Marketed Products

Ventures

 

US and

US and

  

  

    

PRC

    

Others

    

Subtotal

    

PRC

    

Others

    

Subtotal

    

Subtotal

    

PRC

    

Unallocated

    

Total

 

(in US$000)

Revenue from external customers

9,977

269,057

279,034

80,149

80,149

359,183

173,691

532,874

Interest income

438

1

439

439

238

15,198

15,875

Interest expense

(224)

(224)

Equity in earnings of an equity investee, net of tax

35,110

35,110

Income tax expense

(86)

(7)

(93)

107

107

14

(939)

(1,805)

(2,730)

Net (loss)/income attributable to the Company

(83,628)

205,010

121,382

12,971

12,971

134,353

37,180

(2,982)

168,551

Depreciation/ amortization

(3,263)

(250)

(3,513)

(3,513)

(165)

(134)

(3,812)

Additions to non-current assets (other than financial instruments and deferred tax assets)

30,296

110

30,406

30,406

243

15

30,664

 

December 31, 2023

 

Oncology/Immunology

 

Other

 

R&D

Marketed Products

Ventures

 

   

US and

   

  

US and

  

    

PRC

    

Others

    

Subtotal

    

PRC

    

Others

    

Subtotal

    

Subtotal

    

PRC

    

Unallocated

    

Total

 

(in US$000)

Total assets

177,601

24,687

202,288

61,472

2,129

63,601

265,889

163,311

850,573

1,279,773

Property, plant and equipment

98,034

918

98,952

98,952

564

211

99,727

Right-of-use assets

3,454

551

4,005

4,005

366

294

4,665

Leasehold land

11,261

11,261

11,261

11,261

Goodwill

3,064

3,064

Other intangible asset

21

21

Investment in an equity investee

48,411

48,411

Revenue from external customers is after elimination of inter-segment sales. Sales between segments are carried out at mutually agreed terms. The amounts eliminated attributable to sales between PRC and US and others under R&D in Oncology/Immunology segment were US$10,934,000 and US$17,303,000 for the six months ended June 30, 2024 and 2023 respectively.

A summary of customers which accounted for over 10% of the Group’s revenue for the six months ended June 30, 2024 and 2023 is as follows:

Six Months Ended June 30,

    

2024

    

2023

(in US$000)

Customer A

 

76,612

 

269,057

Customer B

 

45,396

 

(note)

Note: Customer did not account for over 10% of the Group’s revenue during the six months ended June 30, 2023.

Customer A and B are included in Oncology/Immunology.

Unallocated expenses mainly represent corporate expenses which include corporate administrative costs, corporate employee benefit expenses and the relevant share-based compensation expense, net of interest income. Unallocated assets mainly comprise cash and cash equivalents and short-term investments.

v3.24.2
Note to Consolidated Statements of Cash Flows
6 Months Ended
Jun. 30, 2024
Note to Consolidated Statements of Cash Flows  
Note to Consolidated Statements of Cash Flows

19.  Note to Consolidated Statements of Cash Flows

Reconciliation of net income for the period to net cash (used in)/generated from operating activities:

 

Six Months Ended June 30, 

    

2024

    

2023

(in US$000)

Net income

26,165

169,468

Adjustments to reconcile net income to net cash (used in)/generated from operating activities

Depreciation and amortization

6,252

3,812

Share-based compensation expense—share options

1,432

3,239

Share-based compensation expense—LTIP

9,880

10,551

Equity in earnings of an equity investee, net of tax

(33,807)

(35,110)

Dividends received from SHPL

14,615

Other adjustments

709

(798)

Changes in operating assets and liabilities

Accounts receivable

(39,879)

(31,348)

Other receivables, prepayments and deposits

(393)

(2,296)

Amounts due from related parties

228

Inventories

3,636

2,815

Accounts payable

7,071

(16,540)

Other payables, accruals and advance receipts

(4,410)

(34,188)

Deferred revenue

(16,363)

142,003

Others

(353)

180

Total changes in operating assets and liabilities

(50,463)

60,626

Net cash (used in)/generated from operating activities

(39,832)

226,403

v3.24.2
Litigation
6 Months Ended
Jun. 30, 2024
Litigation  
Litigation

20.  Litigation

From time to time, the Group may become involved in litigation relating to claims arising from the ordinary course of business. The Group believes that there are currently no claims or actions pending against the Group, the ultimate disposition of which could have a material adverse effect on the Group’s financial position, results of operations or cash flows. However, litigation is subject to inherent uncertainties and the Group’s view of these matters may change in the future. When an unfavorable outcome occurs, there exists the possibility of a material adverse impact on the Group’s financial position, results of operations or cash flows for the periods in which the unfavorable outcome occurs, and potentially in future periods.

On May 17, 2019, Luye Pharma Hong Kong Ltd. (“Luye”) issued a notice to the Group purporting to terminate a distribution agreement that granted the Group exclusive commercial rights to Seroquel in the PRC for failure to meet a pre-specified target. The Group disagrees with this assertion and believes that Luye have no basis for termination. As a result, the Group commenced legal proceedings in 2019 in order to seek damages. On October 21, 2021 (and a decision on costs and interest in December 2021), the Group was awarded an amount of RMB253.2 million (equivalent to US$34.7 million) with interest of 5.5% per annum from the date of the award until payment and recovery of costs of approximately US$2.2 million (collectively the “Award”). On June 27, 2022, Luye provided the Group a bank guarantee of up to RMB286.0 million to cover the Award amounts, pending the outcome of an application by Luye to the High Court of Hong Kong to set aside the Award and subsequent appeals. On July 26, 2022, Luye’s application to set aside the Award was dismissed by the High Court with costs awarded in favor of the Group. On October 7, 2022, Luye filed a Notice of Appeal to the Court of Appeal regarding the dismissal and the notice was accepted on November 8, 2022. On June 6, 2023, an appeal hearing filed by Luye was heard by the Court of Appeal and judgment is awaited. The legal proceedings are ongoing and as no Award amounts have been received as at the issuance date of these condensed consolidated financial statements, no Award amounts have been recognized and no adjustment has been made to Seroquel-related balances as at June 30, 2024. Such Seroquel-related balances include accounts receivable, long-term prepayment, accounts payable and other payables of US$1.1 million, US$0.1 million, US$0.9 million and US$1.1 million respectively.

v3.24.2
Subsequent Events
6 Months Ended
Jun. 30, 2024
Subsequent Events  
Subsequent Events

21.  Subsequent Events

The Group evaluated subsequent events through July 31, 2024, which is the date when the interim unaudited condensed consolidated financial statements were issued.

On July 2, 2024, pursuant to the terms of the strategic partnership agreement entered on January 5, 2021, Inmagene Biopharmaceuticals (“Inmagene”) completed the exercise of options for the exclusive licenses to further develop, manufacture and commercialize two drug candidates worldwide, and the Group received 140,636,592 Inmagene ordinary shares representing approximately 7.5% of shares (fully diluted) in Inmagene.

v3.24.2
Summary of Significant Accounting Policies (Policies)
6 Months Ended
Jun. 30, 2024
Summary of Significant Accounting Policies  
Basis of Presentation

Basis of Presentation

The interim unaudited condensed consolidated financial statements have been prepared in conformity with generally accepted accounting principles in the United States of America (“US GAAP”) for interim financial information. Accordingly, they do not include all of the information and footnotes required by US GAAP for complete financial statements. The interim unaudited condensed consolidated financial statements have been prepared on the same basis as the annual audited consolidated financial statements. In the opinion of management, all adjustments, consisting of normal recurring adjustments necessary for the fair statement of results for the periods presented, have been included. The results of operations of any interim period are not necessarily indicative of the results of operations for the full year or any other interim period.

The comparative year-end condensed balance sheet data was derived from the annual audited consolidated financial statements, but is condensed to the same degree as the interim condensed balance sheet data.

The interim unaudited condensed consolidated financial statements and related disclosures have been prepared with the presumption that users have read or have access to the annual audited consolidated financial statements for the preceding fiscal year.

The preparation of interim unaudited condensed consolidated financial statements in conformity with US GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the interim unaudited condensed consolidated financial statements and the reported amounts of revenue and expenses during the reporting period.

Recent Accounting Pronouncements

Recent Accounting Pronouncements

Amendments that have been issued by the Financial Accounting Standards Board or other standard-setting bodies that do not require adoption until a future date are not expected to have a material impact on the Group’s condensed consolidated financial statements.

v3.24.2
Cash and Cash Equivalents and Short-term Investments (Tables)
6 Months Ended
Jun. 30, 2024
Cash and Cash Equivalents and Short-term Investments  
Schedule of cash and cash equivalents and short term investments

June 30, 

December 31,

    

2024

    

2023

(in US$000)

Cash and Cash Equivalents

Cash at bank and on hand

105,995

129,968

Bank deposits maturing in three months or less

97,958

153,621

203,953

283,589

Short-term Investments

Bank deposits maturing over three months (note)

598,500

602,747

802,453

886,336

Note: The maturities for short-term investments ranged from 91 to 186 days and 91 to 187 days for the six months ended June 30, 2024 and the year ended December 31, 2023 respectively.

    

June 30,

    

December 31,

2024

2023

(in US$000)

US$

744,276

836,718

RMB

52,782

45,772

Hong Kong dollar (“HK$”)

4,870

3,114

£

446

713

Others

79

19

802,453

886,336

v3.24.2
Accounts Receivable (Tables)
6 Months Ended
Jun. 30, 2024
Accounts Receivable  
Schedule of accounts receivable

June 30,

December 31, 

    

2024

    

2023

(in US$000)

Accounts receivable—third parties

156,931

115,169

Accounts receivable—a related party (Note 15(ii))

10

1,896

Allowance for credit losses

(25)

(171)

Accounts receivable, net

156,916

116,894

Schedule of aging analysis based on the relevant invoice dates

    

June 30, 

    

December 31, 

2024

2023

(in US$000)

Not later than 3 months

 

138,947

96,057

Between 3 months to 6 months

 

12,165

11,507

Between 6 months to 1 year

 

4,720

6,439

Later than 1 year

 

1,099

1,166

Accounts receivable—third parties

 

156,931

115,169

Schedule of movements on the allowance for credit losses

    

2024

    

2023

 

(in US$000)

As at January 1

171

60

Increase in allowance for credit losses

25

150

Decrease in allowance due to subsequent collection

(168)

(17)

Exchange difference

(3)

(4)

As at June 30

25

189

v3.24.2
Other Receivables, Prepayments and Deposits (Tables)
6 Months Ended
Jun. 30, 2024
Other Receivables, Prepayments and Deposits  
Schedule of other receivables, prepayments and deposits

June 30, 

December 31, 

    

2024

    

2023

(in US$000)

Prepayments

7,082

7,108

Interest receivables

 

2,842

2,936

Deposits

1,057

1,065

Value-added tax receivables

363

2,166

Others

 

3,370

1,614

 

14,714

14,889

v3.24.2
Inventories (Tables)
6 Months Ended
Jun. 30, 2024
Inventories  
Schedule of inventories, net of provision for excess and obsolete inventories

 

June 30, 

December 31, 

    

2024

    

2023

 

(in US$000)

Raw materials

24,794

26,784

Finished goods

21,647

23,474

46,441

50,258

v3.24.2
Investment in an Equity Investee (Tables)
6 Months Ended
Jun. 30, 2024
Investment in an Equity Investee  
Summary of an equity investee

 

June 30, 

December 31, 

    

2024

    

2023

 

(in US$000)

Shanghai Hutchison Pharmaceuticals Limited (“SHPL”)

80,519

48,411

Summary of balance sheets for SHPL

 

June 30, 

December 31, 

    

2024

    

2023

 

(in US$000)

Current assets

237,504

201,025

Non-current assets

69,310

73,939

Current liabilities

(146,504)

(179,649)

Non-current liabilities

(4,026)

(3,687)

Net assets

156,284

91,628

Summary of statements of operations for SHPL

Six Months Ended June 30,

    

2024

    

2023

(in US$000)

Revenue

 

225,208

235,271

Gross profit

 

166,758

175,750

Interest income

 

338

438

Finance cost (note (a))

 

(1,022)

Profit before taxation

80,213

84,064

Income tax expense (note (b))

(12,294)

(13,840)

Net income (note (c))

 

67,919

70,224

Notes:

(a)

Finance cost was from the accretion of the discount recorded on the dividends payable.

(b)

The main entity within the SHPL group has been granted the High and New Technology Enterprise status (the latest renewal of this status covers the years from 2023 to 2025). Accordingly, the entity was eligible to use a preferential income tax rate of 15% for the six months ended June 30, 2024 and 2023.

(c)

Net income is before elimination of unrealized profits on transactions with the Group. The amounts eliminated were approximately US$152,000 and US$2,000 for the six months ended June 30, 2024 and 2023 respectively.

Summary of reconciliation of the financial information presented to the carrying amount of investment in SHPL

    

2024

    

2023

 

(in US$000)

Opening net assets as at January 1

91,628

141,433

Net income

67,919

70,224

Dividends declared

(146,974)

Deemed distribution

(690)

Discount on dividends payable

3,654

Other comprehensive (loss)/income

(2,573)

1,785

Closing net assets as at June 30

156,284

70,122

Group’s share of net assets

78,142

35,061

Goodwill

2,744

2,795

Elimination of unrealized profits on downstream sales

(367)

(116)

Carrying amount of investment as at June 30

80,519

37,740

Summary of SHPL capital commitments

 

June 30, 

    

2024

 

(in US$000)

Property, plant and equipment

Contracted but not provided for

1,361

v3.24.2
Accounts Payable (Tables)
6 Months Ended
Jun. 30, 2024
Accounts Payable  
Schedule of accounts payable

    

June 30, 

    

December 31, 

2024

2023

(in US$000)

Accounts payable

 

43,398

36,327

Schedule of aging analysis based on the relevant invoice dates

    

June 30, 

    

December 31, 

2024

2023

(in US$000)

Not later than 3 months

 

37,817

33,233

Between 3 months to 6 months

 

3,446

1,058

Between 6 months to 1 year

 

1,018

941

Later than 1 year

 

1,117

1,095

43,398

36,327

v3.24.2
Other Payables, Accruals and Advance Receipts (Tables)
6 Months Ended
Jun. 30, 2024
Other Payables, Accruals and Advance Receipts  
Schedule of other payables, accruals and advance receipts

 

June 30, 

December 31, 

    

2024

    

2023

 

(in US$000)

Accrued research and development expenses

142,667

153,737

Accrued salaries and benefits

26,249

45,048

Accrued selling and marketing expenses

17,930

16,340

Accrued capital expenditures

16,368

23,659

Accrued administrative and other general expenses

15,737

15,777

Advances for inventory purchases

6,076

1,896

Value-added tax payables

3,146

121

Amounts due to related parties (Note 15(ii))

2,150

2,162

Deposits

1,633

1,564

Deferred government grants

635

740

Others

16,627

10,355

249,218

271,399

v3.24.2
Bank Borrowings (Tables)
6 Months Ended
Jun. 30, 2024
Bank Borrowings  
Schedule of bank borrowings

 

June 30, 

December 31, 

     

2024

     

2023

 

(in US$000)

Current

26,468

31,155

Non-current

55,632

48,189

82,100

79,344

Schedule of maturities of bank borrowings

 

June 30, 

December 31, 

    

2024

    

2023

 

(in US$000)

Not later than 1 year

26,468

31,155

Between 1 to 3 years

5,159

3,192

Between 3 to 4 years

3,685

2,872

Between 4 to 5 years

11,054

6,384

Later than 5 years

35,734

35,741

82,100

79,344

v3.24.2
Commitments and Contingencies (Tables)
6 Months Ended
Jun. 30, 2024
Commitments and Contingencies  
Schedule of capital commitments

 

June 30,

    

2024

 

(in US$000)

Property, plant and equipment

Contracted but not provided for

1,613

v3.24.2
Share-based Compensation (Tables)
6 Months Ended
Jun. 30, 2024
Share Option Scheme  
Share-based Compensation  
Schedule of share option activity and related information

Weighted average

Number of

Weighted average

remaining

Aggregate

share

exercise price in

contractual life

intrinsic value

    

options

    

 US$ per share

    

(years)

    

(in US$000)

Outstanding at January 1, 2023

39,521,395

4.34

6.55

11,525

Granted

1,221,900

2.50

Exercised

(6,480,930)

2.30

Cancelled

(2,832,340)

4.61

Expired

(1,893,370)

5.55

Outstanding at December 31, 2023

29,536,655

4.57

6.67

9,924

Granted (note)

1,359,561

3.63

Exercised

(103,450)

2.20

Cancelled

(661,800)

4.63

Expired

(826,925)

5.41

Outstanding at June 30, 2024

29,304,041

4.50

6.30

7,910

Vested and exercisable at December 31, 2023

18,198,170

5.10

5.91

1,753

Vested and exercisable at June 30, 2024

21,511,195

4.93

5.61

2,728

Note: This was granted to an executive director in March 2024 where the number of share options exercisable is subject to certain performance targets based on a market condition covering the 3-year period from 2023 to 2025 which has been reflected in estimating the grant date fair value. The grant date fair value of such award is US$1.29 per share using the Monte Carlo simulation model. Vesting of such award will occur in March 2026 if the performance targets are met.

Schedule of assumptions used in estimating the fair value of share options granted

Six Months Ended

Year Ended

 

    

June 30, 2024

    

December 31, 2023

Weighted average grant date fair value of share options (in US$ per share)

 

1.29

1.14

Significant inputs into the valuation model (weighted average):

 

Exercise price (in US$ per share)

 

3.63

2.50

Share price at effective date of grant (in US$ per share)

 

3.63

2.50

Expected volatility (note (a))

 

54.3

%

53.3

%

Risk-free interest rate (note (b))

 

4.15

%

3.69

%

Contractual life of share options (in years)

 

10

10

Expected dividend yield (note (c))

 

0

%

0

%

Notes:

(a)

The Company calculated its expected volatility with reference to the historical volatility prior to the issuances of share options.

(b)

The risk-free interest rates reference the US Treasury yield curves.

(c)

The Company has not declared or paid any dividends and does not currently expect to do so prior to the exercise of the granted share options, and therefore uses an expected dividend yield of zero in the valuation models.

Schedule of share option exercises

    

Six Months Ended June 30, 

    

2024

    

2023

(in US$000)

Cash received from share option exercises

228

1,058

Total intrinsic value of share option exercises

161

1,898

Schedule of share-based compensation expenses

 

Six Months Ended June 30, 

    

2024

    

2023

 

(in US$000)

Research and development expenses

801

1,664

Selling and administrative expenses

597

1,522

Cost of revenue

34

53

1,432

3,239

LTIP  
Share-based Compensation  
Schedule of granted awards

    

Maximum cash

    

    

amount

Covered

Performance target

Grant date

(in US$ millions)

financial years

determination date

June 5, 2023

54.9

2023

note (a)

March 13, 2024

0.7

note (b)

note (b)

Notes:

(a)

The annual performance target determination date is the date of the announcement of the Group’s annual results for the covered financial year and vesting occurs two business days after the announcement of the Group’s annual results for the financial year falling two years after the covered financial year to which the LTIP award relates.

(b)

This award does not stipulate performance targets and is subject to a vesting schedule of 25% on each of the first, second, third and fourth anniversaries of the date of grant.

Schedule of treasury shares (in ordinary shares equivalent) held by the Trustee

Number of

Cost

    

treasury shares

    

(in US$000)

As at January 1, 2023

19,601,375

76,064

Purchased

2,725,515

9,071

Vested

(4,714,205)

(18,148)

As at December 31, 2023

17,612,685

66,987

Purchased

10,259,133

36,064

Vested

(10,952,145)

(41,371)

As at June 30, 2024

16,919,673

61,680

Schedule of share-based compensation expenses

Six Months Ended June 30, 

    

2024

    

2023

(in US$000)

Research and development expenses

 

6,398

5,700

Selling and administrative expenses

 

3,203

4,614

Cost of revenue

279

237

9,880

10,551

Recorded with a corresponding credit to:

Liability

2,844

1,303

Additional paid-in capital

7,036

9,248

 

9,880

10,551

v3.24.2
Revenue (Tables)
6 Months Ended
Jun. 30, 2024
Schedule of disaggregated revenue

Six Months Ended June 30, 2024

    

Oncology/

    

    

Immunology

Other Ventures

Total

(in US$000)

Invoiced Goods—Marketed Products

 

64,667

64,667

 —Distribution

 

137,044

137,044

Services—Commercialization of Marketed Products

 

28,222

28,222

Research and Development

236

236

License & Collaborations—Services

35,740

35,740

 Royalties

34,907

34,907

 Manufacturing supply

4,865

4,865

 

168,637

137,044

305,681

 

Third parties

 

168,401

135,042

303,443

Related parties (Note 15(i))

 

236

2,002

2,238

168,637

137,044

305,681

Six Months Ended June 30, 2023

Oncology/

    

    

    

Immunology

Other Ventures

Total

(in US$000)

Invoiced Goods—Marketed Products

 

39,808

39,808

 —Distribution

173,691

173,691

Services—Commercialization of Marketed Products

 

25,359

25,359

Research and Development

246

246

License & Collaborations—Services

 

28,718

28,718

 Royalties

14,982

14,982

 Licensing

250,070

250,070

359,183

173,691

532,874

Third parties

 

358,937

169,439

528,376

Related parties (Note 15(i))

 

246

4,252

4,498

359,183

173,691

532,874

Schedule of liability balances from contracts with customers

    

June 30,

    

December 31,

2024

2023

(in US$000)

Deferred revenue

 

  

 

  

Current—Oncology/Immunology segment (note (a))

 

48,100

57,566

Current—Other Ventures segment (note (b))

 

52

73

 

48,152

57,639

Non-current—Oncology/Immunology segment (note (a))

 

60,625

69,480

Total deferred revenue (note (c) and (d))

 

108,777

127,119

Notes:

(a)

Oncology/Immunology segment deferred revenue relates to unamortized upfront and milestone payments, invoiced amounts for royalties where the customer has not yet completed the in-market sale and other advance consideration received.

(b)

Other Ventures segment deferred revenue relates to payments in advance from customers for goods that have not been transferred and services that have not been rendered to the customer as at the reporting date.

(c)

Estimated deferred revenue to be recognized over time as from the date indicated is as follows:

    

June 30,

    

December 31,

2024

2023

(in US$000)

Not later than 1 year

 

48,152

57,639

Between 1 to 2 years

 

33,502

32,797

Between 2 to 3 years

 

21,418

30,918

Between 3 to 4 years

 

1,169

844

Later than 4 years

 

4,536

4,921

 

108,777

127,119

(d)

As at January 1, 2024, deferred revenue was US$127.1 million, of which US$26.3 million was recognized during the six months ended June 30, 2024.

License and collaboration agreement with Takeda Pharmaceuticals  
Schedule of summarized upfront and cumulative milestone payments

    

(in US$000)

Upfront payment

 

400,000

Regulatory approval milestone payment achieved

 

35,000

Schedule of revenue recognized under the agreement

Six Months Ended June 30,

    

2024

    

2023

(in US$000)

Manufacturing supply—Invoiced Marketed Products sales

 

24,806

—Allocated from upfront payment

4,865

Services—Research and Development

14,389

10,372

—Allocated from upfront and milestone payments

14,524

8,615

Royalties—Marketed Products

18,028

Licensing—Allocated from upfront and milestone payments

250,070

 

76,612

269,057

v3.24.2
Research and Development Expenses (Tables)
6 Months Ended
Jun. 30, 2024
Research and Development Expenses  
Summary of research and development expenses

Six Months Ended June 30, 

    

2024

    

2023

 

(in US$000)

Clinical trial related costs

55,728

94,909

Personnel compensation and related costs

36,858

45,410

Other research and development expenses

2,670

4,314

95,256

144,633

v3.24.2
Significant Transactions with Related Parties and Non-Controlling Shareholders of Subsidiaries (Tables)
6 Months Ended
Jun. 30, 2024
Significant Transactions with Related Parties and Non-Controlling Shareholders of Subsidiaries  
Schedule of transactions with related parties

Six Months Ended June 30, 

    

2024

    

2023

 

(in US$000)

Sales to:

Indirect subsidiaries of CK Hutchison Holdings Limited (“CK Hutchison”)

4

1,008

An equity investee

1,998

3,244

2,002

4,252

Revenue from research and development services from:

An equity investee

236

246

Purchase from:

An equity investee

1,452

1,911

Rendering of marketing services from:

Indirect subsidiaries of CK Hutchison

59

Rendering of management services from:

An indirect subsidiary of CK Hutchison

535

498

Schedule of balances with related parties

June 30, 

December 31, 

    

2024

    

2023

 

(in US$000)

Accounts receivable—a related party

An equity investee (note (a))

10

1,896

Amounts due from related parties

An indirect subsidiary of CK Hutchison (note (a))

228

An equity investee (note (a) and (b))

27,736

28,234

27,736

28,462

Other payables, accruals and advance receipts

Indirect subsidiaries of CK Hutchison (note (c) and (e))

1,870

2,017

An equity investee (note (a) and (d))

280

145

2,150

2,162

Other non-current liabilities

An equity investee (note (d))

179

450

An indirect subsidiary of CK Hutchison (note (e))

7,820

7,619

7,999

8,069

Notes:

(a)

Balances with related parties are unsecured, repayable on demand and interest-free. The carrying values of balances with related parties approximate their fair values due to their short-term maturities. No allowance for credit losses has been made for amounts due from related parties for the six months ended June 30, 2024 and the year ended December 31, 2023.

(b)

As at June 30, 2024 and December 31, 2023, dividends receivable of US$26,632,000 and US$27,130,000 was included in amounts due from related parties.

(c)

Amounts due to indirect subsidiaries of CK Hutchison are unsecured, repayable on demand and interest-bearing if not settled within one month.

(d)

Includes other deferred income representing amounts recognized from granting of commercial, promotion and marketing rights.

(e)

As at June 30, 2024 and December 31, 2023, a branding liability payable of US$1,538,000 was included in amounts due to related parties under other payables, accruals and advance receipts. As at June 30, 2024 and December 31, 2023, US$7,820,000 and US$7,619,000 of the branding liability payable was included in other non-current liabilities.

Schedule of transactions with non-controlling shareholders of subsidiaries

Six Months Ended June 30, 

    

2024

    

2023

(in US$000)

Sales

 

29,395

35,933

Purchases

 

127

3,199

Dividends declared

 

1,000

9,068

Distribution service

108

Schedule of balances with non-controlling shareholders of subsidiaries

    

June 30, 

    

December 31, 

2024

2023

(in US$000)

Accounts receivable

 

8,750

7,824

Accounts payable

 

92

27

Other payables, accruals and advance receipts

 

324

309

v3.24.2
Income Taxes (Tables)
6 Months Ended
Jun. 30, 2024
Income Taxes  
Schedule of components of income tax expense

Six Months Ended June 30, 

    

2024

    

2023

(in US$000)

Current tax

HK

1

6

PRC

868

976

US and others

86

52

Total current tax

955

1,034

Deferred income tax expense

1,931

1,696

Income tax expense

2,886

2,730

Schedule of reconciliation of the Group's reported income tax expense to the theoretical tax amount

Six Months Ended June 30, 

    

2024

    

2023

 

(in US$000)

(Loss)/income before income taxes and equity in earnings of an equity investee

(4,756)

137,088

Tax calculated at the statutory tax rate of the Company

(785)

22,620

Tax effects of:

Different tax rates applicable in different jurisdictions

625

(1,423)

Tax valuation allowance

6,513

(2,898)

Preferential tax rate difference

(32)

(39)

Preferential tax deduction and credits

(8,405)

(17,735)

Expenses not deductible for tax purposes

7,548

2,829

Utilization of previously unrecognized tax losses

(3)

(39)

Withholding tax on undistributed earnings of PRC entities

1,670

1,755

Income not subject to tax

(2,852)

(2,478)

Temporary difference

(1,615)

(127)

Others

222

265

Income tax expense

2,886

2,730

v3.24.2
Earnings Per Share (Tables)
6 Months Ended
Jun. 30, 2024
Earnings Per Share  
Schedule of basic earnings per share

Six Months Ended June 30, 

    

2024

    

2023

Weighted average number of outstanding ordinary shares in issue

 

856,030,704

846,928,863

Net income attributable to the Company (US$’000)

 

25,801

168,551

Basic earnings per share attributable to the Company (US$ per share)

 

0.03

0.20

Schedule of diluted earnings per share

Six Months Ended June 30,

    

2024

    

2023

Weighted average number of outstanding ordinary shares in issue

 

856,030,704

 

846,928,863

Effect of share options and LTIP awards

 

16,503,762

 

20,061,747

Weighted average number of outstanding ordinary shares in issue and dilutive ordinary share equivalents outstanding

 

872,534,466

 

866,990,610

Net income attributable to the Company (US$’000)

 

25,801

 

168,551

Diluted earnings per share attributable to the Company (US$ per share)

 

0.03

 

0.19

v3.24.2
Segment Reporting (Tables)
6 Months Ended
Jun. 30, 2024
Segment Reporting  
Schedule of segment information for the reportable segments

 

Six Months Ended June 30, 2024

Oncology/Immunology

Other

R&D

Marketed Products

Ventures

 

US and

US and

  

  

    

PRC

    

Others

    

Subtotal

    

PRC

    

Others

    

Subtotal

    

Subtotal

    

PRC

    

Unallocated

    

Total

 

(in US$000)

Revenue from external customers

7,063

33,778

40,841

84,962

42,834

127,796

168,637

137,044

305,681

Interest income

417

1

418

418

116

20,040

20,574

Interest expense

(914)

(914)

(914)

(362)

(200)

(1,476)

Equity in earnings of an equity investee, net of tax

33,807

33,807

Income tax expense

(100)

(479)

(579)

(530)

(530)

(1,109)

(97)

(1,680)

(2,886)

Net (loss)/income attributable to the Company

(84,530)

16,693

(67,837)

14,771

38,424

53,195

(14,642)

34,149

6,294

25,801

Depreciation/ amortization

(5,937)

(139)

(6,076)

(6,076)

(130)

(46)

(6,252)

Additions to non-current assets (other than financial instruments and deferred tax assets)

3,763

3,763

3,763

1,929

1,234

6,926

 

June 30, 2024

Oncology/Immunology

Other

R&D

Marketed Products

Ventures

 

   

US and

   

  

US and

  

    

PRC

    

Others

    

Subtotal

    

PRC

    

Others

    

Subtotal

    

Subtotal

    

PRC

    

Unallocated

    

Total

 

(in US$000)

Total assets

178,012

30,377

208,389

69,807

38,944

108,751

317,140

193,885

749,843

1,260,868

Property, plant and equipment

93,375

777

94,152

94,152

498

165

94,815

Right-of-use assets

2,813

481

3,294

3,294

1,858

1,240

6,392

Leasehold land

10,931

10,931

10,931

10,931

Goodwill

3,015

3,015

Investment in an equity investee

80,519

80,519

 

Six Months Ended June 30, 2023

 

Oncology/Immunology

 

Other

 

R&D

Marketed Products

Ventures

 

US and

US and

  

  

    

PRC

    

Others

    

Subtotal

    

PRC

    

Others

    

Subtotal

    

Subtotal

    

PRC

    

Unallocated

    

Total

 

(in US$000)

Revenue from external customers

9,977

269,057

279,034

80,149

80,149

359,183

173,691

532,874

Interest income

438

1

439

439

238

15,198

15,875

Interest expense

(224)

(224)

Equity in earnings of an equity investee, net of tax

35,110

35,110

Income tax expense

(86)

(7)

(93)

107

107

14

(939)

(1,805)

(2,730)

Net (loss)/income attributable to the Company

(83,628)

205,010

121,382

12,971

12,971

134,353

37,180

(2,982)

168,551

Depreciation/ amortization

(3,263)

(250)

(3,513)

(3,513)

(165)

(134)

(3,812)

Additions to non-current assets (other than financial instruments and deferred tax assets)

30,296

110

30,406

30,406

243

15

30,664

 

December 31, 2023

 

Oncology/Immunology

 

Other

 

R&D

Marketed Products

Ventures

 

   

US and

   

  

US and

  

    

PRC

    

Others

    

Subtotal

    

PRC

    

Others

    

Subtotal

    

Subtotal

    

PRC

    

Unallocated

    

Total

 

(in US$000)

Total assets

177,601

24,687

202,288

61,472

2,129

63,601

265,889

163,311

850,573

1,279,773

Property, plant and equipment

98,034

918

98,952

98,952

564

211

99,727

Right-of-use assets

3,454

551

4,005

4,005

366

294

4,665

Leasehold land

11,261

11,261

11,261

11,261

Goodwill

3,064

3,064

Other intangible asset

21

21

Investment in an equity investee

48,411

48,411

Summary of customers which accounted for over 10% of the Group's revenue

Six Months Ended June 30,

    

2024

    

2023

(in US$000)

Customer A

 

76,612

 

269,057

Customer B

 

45,396

 

(note)

Note: Customer did not account for over 10% of the Group’s revenue during the six months ended June 30, 2023.

v3.24.2
Note to Consolidated Statements of Cash Flows (Tables)
6 Months Ended
Jun. 30, 2024
Note to Consolidated Statements of Cash Flows  
Schedule of reconciliation of net income for the period to net cash (used in)/generated from operating activities

 

Six Months Ended June 30, 

    

2024

    

2023

(in US$000)

Net income

26,165

169,468

Adjustments to reconcile net income to net cash (used in)/generated from operating activities

Depreciation and amortization

6,252

3,812

Share-based compensation expense—share options

1,432

3,239

Share-based compensation expense—LTIP

9,880

10,551

Equity in earnings of an equity investee, net of tax

(33,807)

(35,110)

Dividends received from SHPL

14,615

Other adjustments

709

(798)

Changes in operating assets and liabilities

Accounts receivable

(39,879)

(31,348)

Other receivables, prepayments and deposits

(393)

(2,296)

Amounts due from related parties

228

Inventories

3,636

2,815

Accounts payable

7,071

(16,540)

Other payables, accruals and advance receipts

(4,410)

(34,188)

Deferred revenue

(16,363)

142,003

Others

(353)

180

Total changes in operating assets and liabilities

(50,463)

60,626

Net cash (used in)/generated from operating activities

(39,832)

226,403

v3.24.2
Organization and Nature of Business (Details) - USD ($)
Jun. 30, 2024
Dec. 31, 2023
Organization and Nature of Business    
Accumulated losses $ (845,068,000) $ (870,869,000)
Cash and cash equivalents 203,953,000 283,589,000
Short-term investments 598,500,000 602,747,000
Unutilized bank borrowing facilities $ 62,608,000 $ 68,069,000
v3.24.2
Cash and Cash Equivalents and Short-term Investments (Details) - USD ($)
6 Months Ended 12 Months Ended
Jun. 30, 2024
Dec. 31, 2023
Cash and Cash Equivalents and Short-term Investments    
Cash at bank and on hand $ 105,995,000 $ 129,968,000
Bank deposits maturing in three months or less 97,958,000 153,621,000
Cash and cash equivalents 203,953,000 283,589,000
Bank deposits maturing over three months 598,500,000 602,747,000
Cash and cash equivalents and short-term investments $ 802,453,000 $ 886,336,000
Minimum    
Cash and Cash Equivalents and Short-term Investments    
Maturities for short-term investments (in days) 91 days 91 days
Maximum    
Cash and Cash Equivalents and Short-term Investments    
Maturities for short-term investments (in days) 186 days 187 days
v3.24.2
Cash and Cash Equivalents and Short-term Investments - Denominated in different currencies (Details) - USD ($)
$ in Thousands
Jun. 30, 2024
Dec. 31, 2023
Cash and Cash Equivalents and Short-term Investments    
Cash and cash equivalents and short-term investments $ 802,453 $ 886,336
US$    
Cash and Cash Equivalents and Short-term Investments    
Cash and cash equivalents and short-term investments 744,276 836,718
RMB    
Cash and Cash Equivalents and Short-term Investments    
Cash and cash equivalents and short-term investments 52,782 45,772
Hong Kong dollar ("HK$")    
Cash and Cash Equivalents and Short-term Investments    
Cash and cash equivalents and short-term investments 4,870 3,114
£    
Cash and Cash Equivalents and Short-term Investments    
Cash and cash equivalents and short-term investments 446 713
Others    
Cash and Cash Equivalents and Short-term Investments    
Cash and cash equivalents and short-term investments $ 79 $ 19
v3.24.2
Accounts Receivable (Details) - USD ($)
$ in Thousands
Jun. 30, 2024
Dec. 31, 2023
Accounts Receivable    
Allowance for credit losses $ (25) $ (171)
Accounts receivable, net 156,916 116,894
Third parties    
Accounts Receivable    
Accounts receivable 156,931 115,169
A related party    
Accounts Receivable    
Accounts receivable $ 10 $ 1,896
v3.24.2
Accounts Receivable- Aging analysis based on the relevant invoice dates (Details) - Third parties - USD ($)
$ in Thousands
Jun. 30, 2024
Dec. 31, 2023
Accounts Receivable    
Accounts receivable $ 156,931 $ 115,169
Not later than 3 months    
Accounts Receivable    
Accounts receivable 138,947 96,057
Between 3 months to 6 months    
Accounts Receivable    
Accounts receivable 12,165 11,507
Between 6 months to 1 year    
Accounts Receivable    
Accounts receivable 4,720 6,439
Later than 1 year    
Accounts Receivable    
Accounts receivable $ 1,099 $ 1,166
v3.24.2
Accounts Receivable- Movements on the allowance for credit losses (Details) - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Allowance for Doubtful Accounts Receivable    
As at January 1 $ 171 $ 60
Increase in allowance for credit losses 25 150
Decrease in allowance due to subsequent collection (168) (17)
Exchange difference (3) (4)
As at June 30 $ 25 $ 189
v3.24.2
Other Receivables, Prepayments and Deposits (Details) - USD ($)
$ in Thousands
6 Months Ended 12 Months Ended
Jun. 30, 2024
Dec. 31, 2023
Other Receivables, Prepayments and Deposits    
Prepayments $ 7,082 $ 7,108
Interest receivables 2,842 2,936
Deposits 1,057 1,065
Value-added tax receivables 363 2,166
Others 3,370 1,614
Total 14,714 14,889
Allowance for credit losses of other receivables, prepayments and deposits $ 0 $ 0
v3.24.2
Inventories (Details) - USD ($)
$ in Thousands
Jun. 30, 2024
Dec. 31, 2023
Inventories    
Raw materials $ 24,794 $ 26,784
Finished goods 21,647 23,474
Total $ 46,441 $ 50,258
v3.24.2
Investment in an Equity Investee (Details) - USD ($)
$ in Thousands
Jun. 30, 2024
Dec. 31, 2023
Jun. 30, 2023
Investments in an Equity Investee      
Investment in an equity investee $ 80,519 $ 48,411  
Shanghai Hutchison Pharmaceuticals Limited ("SHPL")      
Investments in an Equity Investee      
Investment in an equity investee $ 80,519 $ 48,411 $ 37,740
v3.24.2
Investment in an Equity Investee - Summarized balance sheets (Details) - USD ($)
$ in Thousands
Jun. 30, 2024
Dec. 31, 2023
Jun. 30, 2023
Dec. 31, 2022
Summarized balance sheets        
Current assets $ 1,048,260 $ 1,096,839    
Current liabilities (373,288) (403,027)    
Net assets 752,018 743,387 $ 800,017 $ 636,870
SHPL        
Summarized balance sheets        
Current assets 237,504 201,025    
Non-current assets 69,310 73,939    
Current liabilities (146,504) (179,649)    
Non-current liabilities (4,026) (3,687)    
Net assets $ 156,284 $ 91,628    
v3.24.2
Investment in an Equity Investee - Summarized statements of operations (Details) - USD ($)
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Summarized Statements of Operations    
Total revenue $ 305,681,000 $ 532,874,000
Interest income 20,574,000 15,875,000
Profit before taxation (4,756,000) 137,088,000
Income tax expense (note (b)) (2,886,000) (2,730,000)
Net income (note (c)) 26,165,000 169,468,000
SHPL    
Summarized Statements of Operations    
Total revenue 225,208,000 235,271,000
Gross profit 166,758,000 175,750,000
Interest income 338,000 438,000
Finance cost (note (a))   (1,022,000)
Profit before taxation 80,213,000 84,064,000
Income tax expense (note (b)) (12,294,000) (13,840,000)
Net income (note (c)) $ 67,919,000 $ 70,224,000
Preferential income tax rate (as a percent) 15.00% 15.00%
Unrealized profits eliminated $ 152,000 $ 2,000
v3.24.2
Investment in an Equity Investee - Reconciliation of summarized financial information (Details) - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Dec. 31, 2023
Reconciliation of the summarized financial information presented to the carrying amount of investments in an equity investee      
Net income $ 25,801 $ 168,551  
Carrying amount of investment 80,519   $ 48,411
SHPL      
Reconciliation of the summarized financial information presented to the carrying amount of investments in an equity investee      
Opening net assets 91,628 141,433  
Net income 67,919 70,224  
Dividends declared   (146,974)  
Deemed distribution (690)    
Discount on dividends payable   3,654  
Other comprehensive (loss)/income (2,573) 1,785  
Closing net assets 156,284 70,122  
Group's share of net assets 78,142 35,061  
Goodwill 2,744 2,795  
Elimination of unrealized profits on downstream sales (367) (116)  
Carrying amount of investment $ 80,519 $ 37,740 $ 48,411
v3.24.2
Investment in an Equity Investee - Capital Commitments (Details) - Capital commitments
$ in Thousands
6 Months Ended
Jun. 30, 2024
USD ($)
Capital commitments  
Property, plant and equipment - Contracted but not provided for $ 1,613
SHPL  
Capital commitments  
Property, plant and equipment - Contracted but not provided for $ 1,361
v3.24.2
Accounts Payable (Details) - USD ($)
$ in Thousands
Jun. 30, 2024
Dec. 31, 2023
Accounts Payable    
Accounts payable $ 43,398 $ 36,327
v3.24.2
Accounts Payable - An aging analysis based on the relevant invoice dates (Details) - USD ($)
$ in Thousands
Jun. 30, 2024
Dec. 31, 2023
Accounts Payable    
Accounts payable $ 43,398 $ 36,327
Not later than 3 months    
Accounts Payable    
Accounts payable 37,817 33,233
Between 3 months to 6 months    
Accounts Payable    
Accounts payable 3,446 1,058
Between 6 months to 1 year    
Accounts Payable    
Accounts payable 1,018 941
Later than 1 year    
Accounts Payable    
Accounts payable $ 1,117 $ 1,095
v3.24.2
Other Payables, Accruals and Advance Receipts (Details) - USD ($)
$ in Thousands
Jun. 30, 2024
Dec. 31, 2023
Other Payables, Accruals and Advance Receipts    
Accrued research and development expenses $ 142,667 $ 153,737
Accrued salaries and benefits 26,249 45,048
Accrued selling and marketing expenses 17,930 16,340
Accrued capital expenditures 16,368 23,659
Accrued administrative and other general expenses 15,737 15,777
Advances for inventory purchases 6,076 1,896
Value-added tax payables 3,146 121
Deposits 1,633 1,564
Deferred government grants 635 740
Others 16,627 10,355
Total other payables, accruals and advance receipts 249,218 271,399
Related parties    
Other Payables, Accruals and Advance Receipts    
Total other payables, accruals and advance receipts $ 2,150 $ 2,162
v3.24.2
Bank Borrowings - Schedule of Bank Borrowings (Details) - USD ($)
$ in Thousands
Jun. 30, 2024
Dec. 31, 2023
Bank Borrowings    
Current $ 26,468 $ 31,155
Non-current 55,632 48,189
Total $ 82,100 $ 79,344
Weighted average interest rate for outstanding bank borrowings (as a percent) 3.09% 3.41%
v3.24.2
Bank Borrowings - Loan Facilities (Details)
1 Months Ended 6 Months Ended 12 Months Ended
Nov. 30, 2023
CNY (¥)
Oct. 31, 2021
CNY (¥)
Jun. 30, 2024
USD ($)
Dec. 31, 2023
USD ($)
Jun. 30, 2024
CNY (¥)
Jun. 30, 2024
USD ($)
Dec. 31, 2023
CNY (¥)
Dec. 31, 2023
USD ($)
Nov. 30, 2023
USD ($)
Oct. 31, 2021
USD ($)
Short-term working capital loan facility                    
Bank Borrowings                    
Aggregate amount of credit facilities ¥ 300,000,000               $ 41,154,000  
Amount drawn/utilized from the credit facility         ¥ 192,941,000 $ 26,468,000 ¥ 222,941,000 $ 31,155,000    
Short-term working capital loan facility | 1-year China Loan Prime Rate                    
Bank Borrowings                    
Basis spread on variable rate (as a percent) (0.95%)                  
10-year fixed asset loan facility                    
Bank Borrowings                    
Aggregate amount of credit facilities   ¥ 754,880,000               $ 103,554,000
Term (in years)   10 years                
Amount drawn/utilized from the credit facility         ¥ 405,542,000 $ 55,632,000 ¥ 344,840,000 $ 48,189,000    
Capitalized interest     $ 0 $ 1,047,000            
10-year fixed asset loan facility | 5-year China LPR                    
Bank Borrowings                    
Basis spread on variable rate (as a percent)   (0.80%)                
v3.24.2
Bank Borrowings - Schedule of Maturities of Bank Borrowings (Details) - USD ($)
Jun. 30, 2024
Dec. 31, 2023
Bank Borrowings    
Not later than 1 year $ 26,468,000 $ 31,155,000
Between 1 to 3 years 5,159,000 3,192,000
Between 3 to 4 years 3,685,000 2,872,000
Between 4 to 5 years 11,054,000 6,384,000
Later than 5 years 35,734,000 35,741,000
Total 82,100,000 79,344,000
Unutilized bank borrowing facilities $ 62,608,000 $ 68,069,000
v3.24.2
Commitments and Contingencies (Details)
$ in Thousands
6 Months Ended
Jun. 30, 2024
USD ($)
Capital commitments  
Capital commitments  
Property, plant and equipment - Contracted but not provided for $ 1,613
v3.24.2
Share-based Compensation - Share Option Scheme (Details) - Share Option Scheme
6 Months Ended
Jun. 30, 2024
shares
Share-based Compensation  
Aggregate number of shares issuable 41,977,648
Number of shares authorized but unissued 628,640,280
Maximum  
Share-based Compensation  
Expiry period 10 years
Four-year awards  
Share-based Compensation  
Vesting period 4 years
Vesting percentage upon first anniversary 25.00%
Annual vesting percentage after the first anniversary 25.00%
v3.24.2
Share-based Compensation - Share Option Activity (Details) - Share Option Scheme - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 6 Months Ended 12 Months Ended
Mar. 31, 2024
Jun. 30, 2024
Dec. 31, 2023
Dec. 31, 2022
Share-based Compensation        
Weighted average grant date fair value of share options (in US$ per share)   $ 1.29 $ 1.14  
Number of share options        
Outstanding as at beginning of period (in shares)   29,536,655 39,521,395  
Granted (in shares)   1,359,561 1,221,900  
Exercised (in shares)   (103,450) (6,480,930)  
Cancelled (in shares)   (661,800) (2,832,340)  
Expired (in shares)   (826,925) (1,893,370)  
Outstanding as at end of period (in shares)   29,304,041 29,536,655 39,521,395
Vested and exercisable (in shares)   21,511,195 18,198,170  
Weighted average exercise price in US$ per share        
Outstanding balance as at beginning of period (in US$ per share)   $ 4.57 $ 4.34  
Granted (in US$ per share)   3.63 2.50  
Exercised (in US$ per share)   2.20 2.30  
Cancelled (in US$ per share)   4.63 4.61  
Expired (in US$ per share)   5.41 5.55  
Outstanding balance as at end of period (in US$ per share)   4.50 4.57 $ 4.34
Vested and exercisable (in US$ per share)   $ 4.93 $ 5.10  
Weighted average remaining contractual life (years)        
Outstanding (in years)   6 years 3 months 18 days 6 years 8 months 1 day 6 years 6 months 18 days
Vested and exercisable (in years)   5 years 7 months 9 days 5 years 10 months 28 days  
Aggregate intrinsic value in US$'000        
Outstanding (in US$'000)   $ 7,910 $ 9,924 $ 11,525
Vested and exercisable (in US$'000)   $ 2,728 $ 1,753  
Executive Director        
Share-based Compensation        
Vesting period 3 years      
Weighted average grant date fair value of share options (in US$ per share) $ 1.29      
v3.24.2
Share-based Compensation - Share Options Fair value Assumptions (Details) - Share Option Scheme - $ / shares
6 Months Ended 12 Months Ended
Jun. 30, 2024
Dec. 31, 2023
Share-based Compensation    
Weighted average grant date fair value of share options (in US$ per share) $ 1.29 $ 1.14
Significant inputs into the valuation model (weighted average):    
Exercise price (in US$ per share) 3.63 2.50
Share price at effective date of grant (in US$ per share) $ 3.63 $ 2.50
Expected volatility (in percentage) 54.30% 53.30%
Risk-free interest rate (in percentage) 4.15% 3.69%
Contractual life of share options (in years) 10 years 10 years
Expected dividend yield (in percentage) 0.00% 0.00%
v3.24.2
Share-based Compensation - Share Option Exercises (Details) - Share Option Scheme - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Share option values    
Cash received from share option exercises $ 228 $ 1,058
Total intrinsic value of share option exercises $ 161 $ 1,898
v3.24.2
Share-based Compensation - Share Based Compensation Expense (Details) - Share Option Scheme - USD ($)
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Share-based Compensation    
Share-based compensation expense $ 1,432,000 $ 3,239,000
Unrecognized compensation cost $ 4,078,000  
Unrecognized compensation cost - weighted-average remaining service period (in years) 1 year 9 months 18 days  
Research and development expenses    
Share-based Compensation    
Share-based compensation expense $ 801,000 1,664,000
Selling and administrative expenses    
Share-based Compensation    
Share-based compensation expense 597,000 1,522,000
Cost of revenue    
Share-based Compensation    
Share-based compensation expense $ 34,000 $ 53,000
v3.24.2
Share-based Compensation - LTIP (Details) - LTIP - USD ($)
6 Months Ended 12 Months Ended
Mar. 13, 2024
Jun. 05, 2023
Jun. 30, 2024
Jun. 30, 2023
Dec. 31, 2023
Ordinary Shares Held by Trustee - Number of treasury shares          
As at beginning of period     17,612,685 19,601,375 19,601,375
Purchased     10,259,133   2,725,515
Vested     (10,952,145)   (4,714,205)
As at end of period     16,919,673   17,612,685
Ordinary Shares Held by Trustee - Cost          
As at beginning of period     $ 66,987,000 $ 76,064,000 $ 76,064,000
Purchased     36,064,000   9,071,000
Vested     (41,371,000)   (18,148,000)
As at end of period     61,680,000   $ 66,987,000
Awards forfeited     $ 8,574,000 $ 5,041,000  
Shared-based Compensation Award, Performance          
Share-based Compensation          
Maximum cash amount   $ 54,900,000      
Number of business days for vesting after announcement of Group's annual results   2 days      
Vesting, number of years after the covered financial year's announcement of Group's annual results   2 years      
Shared-based Compensation Award, Non-performance          
Share-based Compensation          
Maximum cash amount $ 700,000        
Vesting percentage on each of the first, second, third and fourth anniversaries 25.00%        
v3.24.2
Share-based Compensation - LTIP Share Based Compensation Expense (Details) - LTIP - USD ($)
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Dec. 31, 2023
Share-based Compensation      
Share-based compensation expense $ 9,880,000 $ 10,551,000  
Share-based compensation reclassified from liability to additional paid-in capital 12,424,000 4,563,000  
Share-based compensation recorded as liability 577,000   $ 10,502,000
Unrecognized compensation cost 30,121,000    
Liability      
Share-based Compensation      
Share-based compensation expense 2,844,000 1,303,000  
Additional Paid-in Capital      
Share-based Compensation      
Share-based compensation expense 7,036,000 9,248,000  
Research and development expenses      
Share-based Compensation      
Share-based compensation expense 6,398,000 5,700,000  
Selling and administrative expenses      
Share-based Compensation      
Share-based compensation expense 3,203,000 4,614,000  
Cost of revenue      
Share-based Compensation      
Share-based compensation expense $ 279,000 $ 237,000  
v3.24.2
Revenue (Details) - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Revenue    
Total revenue $ 305,681 $ 532,874
Third parties    
Revenue    
Total revenue 303,443 528,376
Related parties    
Revenue    
Total revenue 2,238 4,498
Goods | Third parties    
Revenue    
Total revenue 204,574 209,247
Goods | Related parties    
Revenue    
Total revenue 2,002 4,252
Invoiced Goods-Marketed Products    
Revenue    
Total revenue 64,667 39,808
Invoiced Goods -Distribution    
Revenue    
Total revenue 137,044 173,691
Services -Commercialization of Marketed Products    
Revenue    
Total revenue 28,222 25,359
Services -Commercialization of Marketed Products | Third parties    
Revenue    
Total revenue 28,222 25,359
Services -Research and Development    
Revenue    
Total revenue 236 246
Services -Research and Development | Related parties    
Revenue    
Total revenue 236 246
License & Collaborations -Services    
Revenue    
Total revenue 35,740 28,718
License & Collaborations -Services | Third parties    
Revenue    
Total revenue 35,740 28,718
License & Collaborations -Royalties    
Revenue    
Total revenue 34,907 14,982
License & Collaborations -Royalties | Third parties    
Revenue    
Total revenue 34,907 14,982
License & Collaborations -Licensing    
Revenue    
Total revenue   250,070
License & Collaborations -Licensing | Third parties    
Revenue    
Total revenue   250,070
License & Collaborations -Manufacturing supply    
Revenue    
Total revenue 4,865  
Oncology/Immunology segment    
Revenue    
Total revenue 168,637 359,183
Oncology/Immunology segment | Third parties    
Revenue    
Total revenue 168,401 358,937
Oncology/Immunology segment | Related parties    
Revenue    
Total revenue 236 246
Oncology/Immunology segment | Invoiced Goods-Marketed Products    
Revenue    
Total revenue 64,667 39,808
Oncology/Immunology segment | Services -Commercialization of Marketed Products    
Revenue    
Total revenue 28,222 25,359
Oncology/Immunology segment | Services -Research and Development    
Revenue    
Total revenue 236 246
Oncology/Immunology segment | License & Collaborations -Services    
Revenue    
Total revenue 35,740 28,718
Oncology/Immunology segment | License & Collaborations -Royalties    
Revenue    
Total revenue 34,907 14,982
Oncology/Immunology segment | License & Collaborations -Licensing    
Revenue    
Total revenue   250,070
Oncology/Immunology segment | License & Collaborations -Manufacturing supply    
Revenue    
Total revenue 4,865  
Other Ventures segment    
Revenue    
Total revenue 137,044 173,691
Other Ventures segment | Third parties    
Revenue    
Total revenue 135,042 169,439
Other Ventures segment | Related parties    
Revenue    
Total revenue 2,002 4,252
Other Ventures segment | Invoiced Goods -Distribution    
Revenue    
Total revenue $ 137,044 $ 173,691
v3.24.2
Revenue - Balances from Contract with Customers and Estimated Deferred Revenue to be Recognized (Details) - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2024
Jan. 01, 2024
Dec. 31, 2023
Revenue      
Deferred revenue-current $ 48,152   $ 57,639
Total deferred revenue 108,777 $ 127,100 127,119
Estimated deferred revenue      
Not later than 1 year 48,152   57,639
Between 1 to 2 years 33,502   32,797
Between 2 to 3 years 21,418   30,918
Between 3 to 4 years 1,169   844
Later than 4 years 4,536   4,921
Total deferred revenue 108,777 $ 127,100 127,119
Deferred revenue recognized 26,300    
Oncology/Immunology segment      
Revenue      
Deferred revenue-current 48,100   57,566
Deferred revenue-noncurrent 60,625   69,480
Other Ventures segment      
Revenue      
Deferred revenue-current $ 52   $ 73
v3.24.2
Revenue - License and Collaboration Agreement (Details) - USD ($)
$ in Thousands
1 Months Ended 6 Months Ended 18 Months Ended
Jan. 23, 2023
Nov. 30, 2023
Jun. 30, 2024
Jun. 30, 2023
Jun. 30, 2024
Revenue from license and collaboration agreements          
Total revenue     $ 305,681 $ 532,874  
Services -Research and Development          
Revenue from license and collaboration agreements          
Total revenue     236 246  
License and collaboration agreement with Takeda Pharmaceuticals          
Revenue from license and collaboration agreements          
Maximum amount of series of payments expected to be received $ 1,130,000        
Upfront payment         $ 400,000
Regulatory approval milestone payment achieved   $ 35,000     35,000
Revenue recognized from upfront payment     18,100   298,100
Revenue recognized from regulatory approval milestone payment     1,300   $ 33,300
Percentage of transaction price allocated to licenses 62.00%        
Percentage of transaction price allocated to other performance obligations 38.00%        
Total revenue     76,612 269,057  
License and collaboration agreement with Takeda Pharmaceuticals | Manufacturing supply -Invoiced Marketed Products sales          
Revenue from license and collaboration agreements          
Total revenue     24,806    
License and collaboration agreement with Takeda Pharmaceuticals | Manufacturing supply -Allocated from upfront payment          
Revenue from license and collaboration agreements          
Total revenue     4,865    
License and collaboration agreement with Takeda Pharmaceuticals | Services -Research and Development          
Revenue from license and collaboration agreements          
Total revenue     14,389 10,372  
License and collaboration agreement with Takeda Pharmaceuticals | Services -Allocated from upfront and milestone payments          
Revenue from license and collaboration agreements          
Total revenue     14,524 8,615  
License and collaboration agreement with Takeda Pharmaceuticals | Royalties-Marketed Products          
Revenue from license and collaboration agreements          
Total revenue     $ 18,028    
License and collaboration agreement with Takeda Pharmaceuticals | Licensing-Allocated from upfront and milestone payments          
Revenue from license and collaboration agreements          
Total revenue       $ 250,070  
v3.24.2
Research and Development Expenses (Details) - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Research and Development Expenses    
Clinical trial related costs $ 55,728 $ 94,909
Personnel compensation and related costs 36,858 45,410
Other research and development expenses 2,670 4,314
Research and development expenses $ 95,256 $ 144,633
v3.24.2
Research and Development Expenses - Additional information (Details) - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Research and Development Expenses    
Research and development expenses $ 95,256 $ 144,633
Collaborative arrangements    
Research and Development Expenses    
Research and development expenses $ 4,100 $ 8,100
v3.24.2
Significant Transactions with Related Parties and Non-Controlling Shareholders of Subsidiaries - Related parties (Details) - USD ($)
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Dec. 31, 2023
Related party transaction      
Total revenue $ 305,681,000 $ 532,874,000  
Accounts receivable 156,916,000   $ 116,894,000
Amounts due from related parties 27,736,000   28,462,000
Other payables, accruals and advance receipts 249,218,000   271,399,000
Other non-current liabilities 19,305,000   15,690,000
Other payables, accruals and advance receipts      
Related party transaction      
Branding liability 1,538,000   1,538,000
Other non-current liabilities      
Related party transaction      
Branding liability 7,820,000   7,619,000
Related parties      
Related party transaction      
Total revenue 2,238,000 4,498,000  
Other payables, accruals and advance receipts 2,150,000   2,162,000
Other non-current liabilities 7,999,000   8,069,000
Indirect subsidiaries of CK Hutchison      
Related party transaction      
Amounts due from related parties     228,000
Other payables, accruals and advance receipts 1,870,000   2,017,000
Other non-current liabilities $ 7,820,000   7,619,000
Period of repayable on demand and interest-bearing (in months) 1 month    
An equity investee      
Related party transaction      
Purchases $ 1,452,000 1,911,000  
Accounts receivable 10,000   1,896,000
Amounts due from related parties 27,736,000   28,234,000
Other payables, accruals and advance receipts 280,000   145,000
Other non-current liabilities 179,000   450,000
An equity investee | Due from a related party      
Related party transaction      
Dividends receivable 26,632,000   $ 27,130,000
Sales | Related parties      
Related party transaction      
Total revenue 2,002,000 4,252,000  
Sales | Indirect subsidiaries of CK Hutchison      
Related party transaction      
Total revenue 4,000 1,008,000  
Sales | An equity investee      
Related party transaction      
Total revenue 1,998,000 3,244,000  
Research and development services | An equity investee      
Related party transaction      
Total revenue 236,000 246,000  
Marketing services | Indirect subsidiaries of CK Hutchison      
Related party transaction      
Expenses   59,000  
Management services | Indirect subsidiaries of CK Hutchison      
Related party transaction      
Expenses $ 535,000 $ 498,000  
v3.24.2
Significant Transactions with Related Parties and Non-Controlling Shareholders of Subsidiaries - Non-controlling shareholders of subsidiaries (Details) - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Dec. 31, 2023
Transactions with non-controlling shareholders of subsidiaries:      
Sales $ 305,681 $ 532,874  
Dividends declared 1,000 9,068  
Balances with non-controlling shareholders of subsidiaries included in:      
Accounts receivable 156,916   $ 116,894
Accounts payable 43,398   36,327
Other payables, accruals and advance receipts 249,218   271,399
Non-controlling shareholders of subsidiaries      
Transactions with non-controlling shareholders of subsidiaries:      
Sales 29,395 35,933  
Purchases 127 3,199  
Dividends declared 1,000 $ 9,068  
Distribution service 108    
Balances with non-controlling shareholders of subsidiaries included in:      
Accounts receivable 8,750   7,824
Accounts payable 92   27
Other payables, accruals and advance receipts $ 324   $ 309
v3.24.2
Income Taxes (Details) - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Income tax expense    
Total current tax $ 955 $ 1,034
Deferred income tax expense 1,931 1,696
Income tax expense 2,886 2,730
Reconciliation of reported income tax expense to the theoretical tax amount    
(Loss)/income before income taxes and equity in earnings of an equity investee (4,756) 137,088
Tax calculated at the statutory tax rate of the Company (785) 22,620
Different tax rates applicable in different jurisdictions 625 (1,423)
Tax valuation allowance 6,513 (2,898)
Preferential tax rate difference (32) (39)
Preferential tax deduction and credits (8,405) (17,735)
Expenses not deductible for tax purposes 7,548 2,829
Utilization of previously unrecognized tax losses (3) (39)
Withholding tax on undistributed earnings of PRC entities 1,670 1,755
Income not subject to tax (2,852) (2,478)
Temporary difference (1,615) (127)
Others 222 265
Income tax expense 2,886 2,730
HK    
Income tax expense    
Total current tax 1 6
PRC    
Income tax expense    
Total current tax 868 976
US and others    
Income tax expense    
Total current tax $ 86 $ 52
v3.24.2
Earnings Per Share - Basic (Details) - USD ($)
$ / shares in Units, $ in Thousands
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Basic earnings per share    
Weighted average number of outstanding ordinary shares in issue 856,030,704 846,928,863
Net (loss)/income attributable to the Company $ 25,801 $ 168,551
Basic earnings per share attributable to the Company (US$ per share) $ 0.03 $ 0.20
v3.24.2
Earnings Per Share - Diluted (Details) - USD ($)
$ / shares in Units, $ in Thousands
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Diluted earnings per share    
Weighted average number of outstanding ordinary shares in issue 856,030,704 846,928,863
Effect of share options and LTIP awards 16,503,762 20,061,747
Weighted average number of outstanding ordinary shares in issue and dilutive ordinary share equivalents outstanding 872,534,466 866,990,610
Net (loss)/income attributable to the Company $ 25,801 $ 168,551
Diluted earnings per share attributable to the Company (US$ per share) $ 0.03 $ 0.19
v3.24.2
Segment Reporting - Segment Information (Details)
$ in Thousands
6 Months Ended
Jun. 30, 2024
USD ($)
area
Jun. 30, 2023
USD ($)
Dec. 31, 2023
USD ($)
Segment Reporting      
Revenue from external customers $ 305,681 $ 532,874  
Interest income 20,574 15,875  
Interest expense (1,476) (224)  
Equity in earnings of an equity investee, net of tax 33,807 35,110  
Income tax expense (2,886) (2,730)  
Net (loss)/income attributable to the Company 25,801 168,551  
Depreciation/amortization (6,252) (3,812)  
Additions to non-current assets (other than financial instruments and deferred tax assets) 6,926 30,664  
Segment information      
Total assets 1,260,868   $ 1,279,773
Property, plant and equipment 94,815   99,727
Right-of-use assets 6,392   4,665
Leasehold land 10,931   11,261
Goodwill 3,015   3,064
Other intangible asset     21
Investment in an equity investee $ 80,519   48,411
Oncology/Immunology segment      
Segment Reporting      
Number of core business areas in Oncology/Immunology segment | area 2    
Revenue from external customers $ 168,637 359,183  
Other Ventures segment      
Segment Reporting      
Revenue from external customers 137,044 173,691  
Reportable segment | Oncology/Immunology segment      
Segment Reporting      
Revenue from external customers 168,637 359,183  
Interest income 418 439  
Interest expense (914)    
Income tax expense (1,109) 14  
Net (loss)/income attributable to the Company (14,642) 134,353  
Depreciation/amortization (6,076) (3,513)  
Additions to non-current assets (other than financial instruments and deferred tax assets) 3,763 30,406  
Segment information      
Total assets 317,140   265,889
Property, plant and equipment 94,152   98,952
Right-of-use assets 3,294   4,005
Leasehold land 10,931   11,261
Reportable segment | Oncology/Immunology segment | R&D      
Segment Reporting      
Revenue from external customers 40,841 279,034  
Interest income 418 439  
Interest expense (914)    
Income tax expense (579) (93)  
Net (loss)/income attributable to the Company (67,837) 121,382  
Depreciation/amortization (6,076) (3,513)  
Additions to non-current assets (other than financial instruments and deferred tax assets) 3,763 30,406  
Segment information      
Total assets 208,389   202,288
Property, plant and equipment 94,152   98,952
Right-of-use assets 3,294   4,005
Leasehold land 10,931   11,261
Reportable segment | Oncology/Immunology segment | R&D | PRC      
Segment Reporting      
Revenue from external customers 7,063 9,977  
Interest income 417 438  
Interest expense (914)    
Income tax expense (100) (86)  
Net (loss)/income attributable to the Company (84,530) (83,628)  
Depreciation/amortization (5,937) (3,263)  
Additions to non-current assets (other than financial instruments and deferred tax assets) 3,763 30,296  
Segment information      
Total assets 178,012   177,601
Property, plant and equipment 93,375   98,034
Right-of-use assets 2,813   3,454
Leasehold land 10,931   11,261
Reportable segment | Oncology/Immunology segment | R&D | US and others      
Segment Reporting      
Revenue from external customers 33,778 269,057  
Interest income 1 1  
Income tax expense (479) (7)  
Net (loss)/income attributable to the Company 16,693 205,010  
Depreciation/amortization (139) (250)  
Additions to non-current assets (other than financial instruments and deferred tax assets)   110  
Segment information      
Total assets 30,377   24,687
Property, plant and equipment 777   918
Right-of-use assets 481   551
Reportable segment | Oncology/Immunology segment | Marketed Products      
Segment Reporting      
Revenue from external customers 127,796 80,149  
Income tax expense (530) 107  
Net (loss)/income attributable to the Company 53,195 12,971  
Segment information      
Total assets 108,751   63,601
Reportable segment | Oncology/Immunology segment | Marketed Products | PRC      
Segment Reporting      
Revenue from external customers 84,962 80,149  
Income tax expense (530) 107  
Net (loss)/income attributable to the Company 14,771 12,971  
Segment information      
Total assets 69,807   61,472
Reportable segment | Oncology/Immunology segment | Marketed Products | US and others      
Segment Reporting      
Revenue from external customers 42,834    
Net (loss)/income attributable to the Company 38,424    
Segment information      
Total assets 38,944   2,129
Reportable segment | Other Ventures segment | PRC      
Segment Reporting      
Revenue from external customers 137,044 173,691  
Interest income 116 238  
Interest expense (362)    
Equity in earnings of an equity investee, net of tax 33,807 35,110  
Income tax expense (97) (939)  
Net (loss)/income attributable to the Company 34,149 37,180  
Depreciation/amortization (130) (165)  
Additions to non-current assets (other than financial instruments and deferred tax assets) 1,929 243  
Segment information      
Total assets 193,885   163,311
Property, plant and equipment 498   564
Right-of-use assets 1,858   366
Goodwill 3,015   3,064
Other intangible asset     21
Investment in an equity investee 80,519   48,411
Unallocated      
Segment Reporting      
Interest income 20,040 15,198  
Interest expense (200) (224)  
Income tax expense (1,680) (1,805)  
Net (loss)/income attributable to the Company 6,294 (2,982)  
Depreciation/amortization (46) (134)  
Additions to non-current assets (other than financial instruments and deferred tax assets) 1,234 $ 15  
Segment information      
Total assets 749,843   850,573
Property, plant and equipment 165   211
Right-of-use assets $ 1,240   $ 294
v3.24.2
Segment Reporting - Elimination (Details) - USD ($)
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Segment Reporting    
Revenue from external customers $ 305,681,000 $ 532,874,000
Oncology/Immunology segment    
Segment Reporting    
Revenue from external customers 168,637,000 359,183,000
Intersegment elimination | Oncology/Immunology segment | R&D    
Segment Reporting    
Revenue from external customers $ 10,934,000 $ 17,303,000
v3.24.2
Segment Reporting - Major Customers (Details) - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Segment Reporting    
Total revenue $ 305,681 $ 532,874
Customer A    
Segment Reporting    
Total revenue 76,612 $ 269,057
Customer B    
Segment Reporting    
Total revenue $ 45,396  
v3.24.2
Note to Consolidated Statements of Cash Flows (Details) - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Operating activities    
Net income $ 26,165 $ 169,468
Adjustments to reconcile net income to net cash (used in)/generated from operating activities    
Depreciation and amortization 6,252 3,812
Share-based compensation expense-share options 1,432 3,239
Share-based compensation expense-LTIP 9,880 10,551
Equity in earnings of an equity investee, net of tax (33,807) (35,110)
Dividends received from SHPL   14,615
Other adjustments 709 (798)
Changes in operating assets and liabilities    
Accounts receivable (39,879) (31,348)
Other receivables, prepayments and deposits (393) (2,296)
Amounts due from related parties 228  
Inventories 3,636 2,815
Accounts payable 7,071 (16,540)
Other payables, accruals and advance receipts (4,410) (34,188)
Deferred revenue (16,363) 142,003
Others (353) 180
Total changes in operating assets and liabilities (50,463) 60,626
Net cash (used in)/generated from operating activities $ (39,832) $ 226,403
v3.24.2
Litigation (Details)
$ in Thousands, ¥ in Millions
Oct. 21, 2021
USD ($)
Oct. 21, 2021
CNY (¥)
Jun. 30, 2024
USD ($)
claim
Dec. 31, 2023
USD ($)
Jun. 27, 2022
CNY (¥)
Number of claims or actions pending, which ultimate disposition could have a material adverse effect on the Group's results of operations | claim     0    
Damages awarded $ 34,700 ¥ 253.2      
Losses annual interest rate 5.50% 5.50%      
Recovery of costs $ 2,200        
Bank guarantee | ¥         ¥ 286.0
Accounts receivable     $ 156,916 $ 116,894  
Accounts payable     43,398 36,327  
Other payables     249,218 $ 271,399  
Seroquel          
Accounts receivable     1,100    
Long-term prepayment     100    
Accounts payable     900    
Other payables     $ 1,100    
v3.24.2
Subsequent Events (Details) - Subsequent Events - Inmagene
Jul. 02, 2024
shares
Subsequent events  
Ordinary shares which completed exercise of options, received by the group 140,636,592
Percentage of shares 7.50%